Details
| Original language | English |
|---|---|
| Pages (from-to) | 437-439 |
| Number of pages | 3 |
| Journal | Clinical and Experimental Dermatology |
| Volume | 35 |
| Issue number | 4 |
| Publication status | Published - 19 Apr 2010 |
Abstract
Photoageing is generally treated by ablative procedures that injure the epidermis and basement membrane, and lead to fibrosis of the dermis. Percutaneous collagen induction (PCI) therapy is an alternative treatment for photoaged skin that does not result in clinical signs of dermal fibrosis. In this study, the immediate effects of PCI on the skin were assessed, including the systemic inflammatory response and the production and gene expression of transforming growth factor (TGF) isoforms β1, β2 and β3. Eighty rats were split into four groups: group 1 (n = 24; PCI plus skin care); group 2 (n = 24; skin care only); group 3 (n = 24; PCI only) and group 4 (n = 8; controls). Microarray analysis showed that TGF-β3, an essential marker for preventing scarring, was upregulated and expressed for 2 weeks postoperatively. PCI might offer a regenerative therapy to improve skin appearance and quality and to improve or even prevent scarring.
ASJC Scopus subject areas
- Medicine(all)
- Dermatology
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In: Clinical and Experimental Dermatology, Vol. 35, No. 4, 19.04.2010, p. 437-439.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Percutaneous collagen induction. Scarless skin rejuvenation:fact or fiction?
AU - Aust, M. C.
AU - Reimers, K.
AU - Gohritz, A.
AU - Jahn, S.
AU - Stahl, F.
AU - Repenning, C.
AU - Scheper, T.
AU - Altintas, M. A.
AU - Schwaiger, N.
AU - Redeker, J.
AU - Vogt, P. M.
PY - 2010/4/19
Y1 - 2010/4/19
N2 - Photoageing is generally treated by ablative procedures that injure the epidermis and basement membrane, and lead to fibrosis of the dermis. Percutaneous collagen induction (PCI) therapy is an alternative treatment for photoaged skin that does not result in clinical signs of dermal fibrosis. In this study, the immediate effects of PCI on the skin were assessed, including the systemic inflammatory response and the production and gene expression of transforming growth factor (TGF) isoforms β1, β2 and β3. Eighty rats were split into four groups: group 1 (n = 24; PCI plus skin care); group 2 (n = 24; skin care only); group 3 (n = 24; PCI only) and group 4 (n = 8; controls). Microarray analysis showed that TGF-β3, an essential marker for preventing scarring, was upregulated and expressed for 2 weeks postoperatively. PCI might offer a regenerative therapy to improve skin appearance and quality and to improve or even prevent scarring.
AB - Photoageing is generally treated by ablative procedures that injure the epidermis and basement membrane, and lead to fibrosis of the dermis. Percutaneous collagen induction (PCI) therapy is an alternative treatment for photoaged skin that does not result in clinical signs of dermal fibrosis. In this study, the immediate effects of PCI on the skin were assessed, including the systemic inflammatory response and the production and gene expression of transforming growth factor (TGF) isoforms β1, β2 and β3. Eighty rats were split into four groups: group 1 (n = 24; PCI plus skin care); group 2 (n = 24; skin care only); group 3 (n = 24; PCI only) and group 4 (n = 8; controls). Microarray analysis showed that TGF-β3, an essential marker for preventing scarring, was upregulated and expressed for 2 weeks postoperatively. PCI might offer a regenerative therapy to improve skin appearance and quality and to improve or even prevent scarring.
UR - http://www.scopus.com/inward/record.url?scp=77951235264&partnerID=8YFLogxK
U2 - 10.1111/j.1365-2230.2010.03779.x
DO - 10.1111/j.1365-2230.2010.03779.x
M3 - Article
C2 - 20337652
AN - SCOPUS:77951235264
VL - 35
SP - 437
EP - 439
JO - Clinical and Experimental Dermatology
JF - Clinical and Experimental Dermatology
SN - 0307-6938
IS - 4
ER -