Details
| Original language | English |
|---|---|
| Pages (from-to) | 5239-5243 |
| Number of pages | 5 |
| Journal | Angewandte Chemie - International Edition |
| Volume | 51 |
| Issue number | 21 |
| Publication status | Published - 21 May 2012 |
Abstract
Genetic analysis of biosynthetic gene clusters is becoming an accepted tool to predict the stereochemical outcome of a biosynthesis. However, in the case of pellasoren, one chiral center was not predicted correctly. The absolute configuration was verified by total synthesis, which also demonstrated that stereoselective protonations can be successfully applied to natural products synthesis.
Keywords
- biosynthesis, myxobacteria, natural products, Sorangium cellulosum, total synthesis
ASJC Scopus subject areas
- Chemical Engineering(all)
- Catalysis
- Chemistry(all)
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In: Angewandte Chemie - International Edition, Vol. 51, No. 21, 21.05.2012, p. 5239-5243.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Pellasoren
T2 - Structure elucidation, biosynthesis, and total synthesis of a cytotoxic secondary metabolite from Sorangium cellulosum
AU - Jahns, Christine
AU - Hoffmann, Thomas
AU - Müller, Stefan
AU - Gerth, Klaus
AU - Washausen, Peter
AU - Höfle, Gerhard
AU - Reichenbach, Hans
AU - Kalesse, Markus
AU - Müller, Rolf
PY - 2012/5/21
Y1 - 2012/5/21
N2 - Genetic analysis of biosynthetic gene clusters is becoming an accepted tool to predict the stereochemical outcome of a biosynthesis. However, in the case of pellasoren, one chiral center was not predicted correctly. The absolute configuration was verified by total synthesis, which also demonstrated that stereoselective protonations can be successfully applied to natural products synthesis.
AB - Genetic analysis of biosynthetic gene clusters is becoming an accepted tool to predict the stereochemical outcome of a biosynthesis. However, in the case of pellasoren, one chiral center was not predicted correctly. The absolute configuration was verified by total synthesis, which also demonstrated that stereoselective protonations can be successfully applied to natural products synthesis.
KW - biosynthesis
KW - myxobacteria
KW - natural products
KW - Sorangium cellulosum
KW - total synthesis
UR - http://www.scopus.com/inward/record.url?scp=84862095678&partnerID=8YFLogxK
U2 - 10.1002/anie.201200327
DO - 10.1002/anie.201200327
M3 - Article
C2 - 22488911
AN - SCOPUS:84862095678
VL - 51
SP - 5239
EP - 5243
JO - Angewandte Chemie - International Edition
JF - Angewandte Chemie - International Edition
SN - 1433-7851
IS - 21
ER -