Details
| Original language | English |
|---|---|
| Pages (from-to) | 6013–6023 |
| Number of pages | 11 |
| Journal | MACROMOLECULES |
| Volume | 57 |
| Issue number | 13 |
| Early online date | 14 Jun 2024 |
| Publication status | Published - 9 Jul 2024 |
Abstract
Hydrophilic polymers have found ubiquitous use in drug delivery and novel polymer materials to advance drug delivery systems are highly sought after. Herein, an amylose mimic (PEGose) was combined with poly(lactic acid) (PLA) in an amphiphilic block copolymer to form PEG-free nanoparticles as an alternative to PEG-based nanomedicines. The block copolymer self-assembled into 150-200 nm particles with a narrow dispersity in aqueous environment. The formed nanoparticles were capable of encapsulation, the sustained release of both hydrophilic and hydrophobic dyes. Moreover, the nanoparticles were found to be remarkably stable and had a very low cytotoxicity and a high propensity to penetrate cells. These results highlight the potential of PEGose-b-PLA to be used in drug delivery with a new hydrophilic building block.
ASJC Scopus subject areas
- Chemistry(all)
- Organic Chemistry
- Materials Science(all)
- Polymers and Plastics
- Chemistry(all)
- Inorganic Chemistry
- Materials Science(all)
- Materials Chemistry
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In: MACROMOLECULES, Vol. 57, No. 13, 09.07.2024, p. 6013–6023.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - PEGose Block Poly(lactic acid) Nanoparticles for Cargo Delivery
AU - Masclef, Jean Baptiste
AU - Acs, Emmanuelle M.N.
AU - Koehnke, Jesko
AU - Prunet, Joëlle
AU - Schmidt, Bernhard V.K.J.
N1 - Publisher Copyright: © 2024 The Authors. Published by American Chemical Society.
PY - 2024/7/9
Y1 - 2024/7/9
N2 - Hydrophilic polymers have found ubiquitous use in drug delivery and novel polymer materials to advance drug delivery systems are highly sought after. Herein, an amylose mimic (PEGose) was combined with poly(lactic acid) (PLA) in an amphiphilic block copolymer to form PEG-free nanoparticles as an alternative to PEG-based nanomedicines. The block copolymer self-assembled into 150-200 nm particles with a narrow dispersity in aqueous environment. The formed nanoparticles were capable of encapsulation, the sustained release of both hydrophilic and hydrophobic dyes. Moreover, the nanoparticles were found to be remarkably stable and had a very low cytotoxicity and a high propensity to penetrate cells. These results highlight the potential of PEGose-b-PLA to be used in drug delivery with a new hydrophilic building block.
AB - Hydrophilic polymers have found ubiquitous use in drug delivery and novel polymer materials to advance drug delivery systems are highly sought after. Herein, an amylose mimic (PEGose) was combined with poly(lactic acid) (PLA) in an amphiphilic block copolymer to form PEG-free nanoparticles as an alternative to PEG-based nanomedicines. The block copolymer self-assembled into 150-200 nm particles with a narrow dispersity in aqueous environment. The formed nanoparticles were capable of encapsulation, the sustained release of both hydrophilic and hydrophobic dyes. Moreover, the nanoparticles were found to be remarkably stable and had a very low cytotoxicity and a high propensity to penetrate cells. These results highlight the potential of PEGose-b-PLA to be used in drug delivery with a new hydrophilic building block.
UR - http://www.scopus.com/inward/record.url?scp=85196413816&partnerID=8YFLogxK
U2 - 10.1021/acs.macromol.4c00528
DO - 10.1021/acs.macromol.4c00528
M3 - Article
AN - SCOPUS:85196413816
VL - 57
SP - 6013
EP - 6023
JO - MACROMOLECULES
JF - MACROMOLECULES
SN - 0024-9297
IS - 13
ER -