Details
| Original language | English |
|---|---|
| Article number | 401 |
| Journal | ecancer medical science |
| Volume | 8 |
| Issue number | 1 |
| Publication status | Published - 11 Feb 2014 |
Abstract
Biobanks represent key resources for clinico-genomic research and are needed to pave the way to personalised medicine. To achieve this goal, it is crucial that scientists can securely access and share high-quality biomaterial and related data. Therefore, there is a growing interest in integrating biobanks into larger biomedical information and communication technology (ICT) infrastructures. The European project p-medicine is currently building an innovative ICT infrastructure to meet this need. This platform provides tools and services for conducting research and clinical trials in personalised medicine. In this paper, we describe one of its main components, the biobank access framework p-BioSPRE (p-medicine Biospecimen Search and Project Request Engine). This generic framework enables and simplifies access to existing biobanks, but also to offer own biomaterial collections to research communities, and to manage biobank specimens and related clinical data over the ObTiMA Trial Biomaterial Manager. p-BioSPRE takes into consideration all relevant ethical and legal standards, e.g., safeguarding donors' personal rights and enabling biobanks to keep control over the donated material and related data. The framework thus enables secure sharing of biomaterial within open and closed research communities, while flexibly integrating related clinical and omics data. Although the development of the framework is mainly driven by user scenarios from the cancer domain, in this case, acute lymphoblastic leukaemia and Wilms tumour, it can be extended to further disease entities.
Keywords
- Biobank access, IDB, ObTiMA, P-BioSPRE, Pp-biobank wrapper, Specimen management, Trial Biomaterial Manager
ASJC Scopus subject areas
- Medicine(all)
- Oncology
- Biochemistry, Genetics and Molecular Biology(all)
- Cancer Research
Sustainable Development Goals
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In: ecancer medical science, Vol. 8, No. 1, 401, 11.02.2014.
Research output: Contribution to journal › Review article › Research › peer review
}
TY - JOUR
T1 - P-BioSPRE - An information and communication technology framework for transnational biomaterial sharing and access
AU - Weiler, Gabriele
AU - Schröder, Christina
AU - Schera, Fatima
AU - Dobkowicz, Matthias
AU - Kiefer, Stephan
AU - Heidtke, Karsten R.
AU - Hänold, Stefanie
AU - Nwankwo, Iheanyi
AU - Forgó, Nikolaus
AU - Stanulla, Martin
AU - Eckert, Cornelia
AU - Graf, Norbert
PY - 2014/2/11
Y1 - 2014/2/11
N2 - Biobanks represent key resources for clinico-genomic research and are needed to pave the way to personalised medicine. To achieve this goal, it is crucial that scientists can securely access and share high-quality biomaterial and related data. Therefore, there is a growing interest in integrating biobanks into larger biomedical information and communication technology (ICT) infrastructures. The European project p-medicine is currently building an innovative ICT infrastructure to meet this need. This platform provides tools and services for conducting research and clinical trials in personalised medicine. In this paper, we describe one of its main components, the biobank access framework p-BioSPRE (p-medicine Biospecimen Search and Project Request Engine). This generic framework enables and simplifies access to existing biobanks, but also to offer own biomaterial collections to research communities, and to manage biobank specimens and related clinical data over the ObTiMA Trial Biomaterial Manager. p-BioSPRE takes into consideration all relevant ethical and legal standards, e.g., safeguarding donors' personal rights and enabling biobanks to keep control over the donated material and related data. The framework thus enables secure sharing of biomaterial within open and closed research communities, while flexibly integrating related clinical and omics data. Although the development of the framework is mainly driven by user scenarios from the cancer domain, in this case, acute lymphoblastic leukaemia and Wilms tumour, it can be extended to further disease entities.
AB - Biobanks represent key resources for clinico-genomic research and are needed to pave the way to personalised medicine. To achieve this goal, it is crucial that scientists can securely access and share high-quality biomaterial and related data. Therefore, there is a growing interest in integrating biobanks into larger biomedical information and communication technology (ICT) infrastructures. The European project p-medicine is currently building an innovative ICT infrastructure to meet this need. This platform provides tools and services for conducting research and clinical trials in personalised medicine. In this paper, we describe one of its main components, the biobank access framework p-BioSPRE (p-medicine Biospecimen Search and Project Request Engine). This generic framework enables and simplifies access to existing biobanks, but also to offer own biomaterial collections to research communities, and to manage biobank specimens and related clinical data over the ObTiMA Trial Biomaterial Manager. p-BioSPRE takes into consideration all relevant ethical and legal standards, e.g., safeguarding donors' personal rights and enabling biobanks to keep control over the donated material and related data. The framework thus enables secure sharing of biomaterial within open and closed research communities, while flexibly integrating related clinical and omics data. Although the development of the framework is mainly driven by user scenarios from the cancer domain, in this case, acute lymphoblastic leukaemia and Wilms tumour, it can be extended to further disease entities.
KW - Biobank access
KW - IDB
KW - ObTiMA
KW - P-BioSPRE
KW - Pp-biobank wrapper
KW - Specimen management
KW - Trial Biomaterial Manager
UR - http://www.scopus.com/inward/record.url?scp=84894450292&partnerID=8YFLogxK
U2 - 10.3332/ecancer.2014.401
DO - 10.3332/ecancer.2014.401
M3 - Review article
AN - SCOPUS:84894450292
VL - 8
JO - ecancer medical science
JF - ecancer medical science
SN - 1754-6605
IS - 1
M1 - 401
ER -