Details
| Original language | English |
|---|---|
| Article number | uqad020 |
| Journal | Microlife |
| Volume | 4 |
| Publication status | Published - 11 Apr 2023 |
Abstract
Streptomyces are prolific antibiotic producers that thrive in soil, where they encounter diverse environmental cues, including osmotic challenges caused by rainfall and drought. Despite their enormous value in the biotechnology sector, which often relies on ideal growth conditions, how Streptomyces react and adapt to osmotic stress is heavily understudied. This is likely due to their complex developmental biology and an exceptionally broad number of signal transduction systems.With this review, we provide an overview of Streptomyces' responses to osmotic stress signals and draw attention to open questions in this research area.We discuss putative osmolyte transport systems that are likely involved in ion balance control and osmoadaptation and the role of alternative sigma factors and two-component systems (TCS) in osmoregulation. Finally, we highlight the current view on the role of the second messenger c-di-AMP in cell differentiation and the osmotic stress responses with specific emphasis on the two models, S. coelicolor and S. venezuelae.
Keywords
- AtaC, DisA, Streptomyces, c-di-AMP, osmotic stress
ASJC Scopus subject areas
- Immunology and Microbiology(all)
- General Immunology and Microbiology
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In: Microlife, Vol. 4, uqad020, 11.04.2023.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Osmotic stress responses and the biology of the second messenger c-di-AMP in Streptomyces
AU - Bhowmick, Sukanya
AU - Shenouda, Mary Labib
AU - Tschowri, Natalia
N1 - Publisher Copyright: © The Author(s) 2023.
PY - 2023/4/11
Y1 - 2023/4/11
N2 - Streptomyces are prolific antibiotic producers that thrive in soil, where they encounter diverse environmental cues, including osmotic challenges caused by rainfall and drought. Despite their enormous value in the biotechnology sector, which often relies on ideal growth conditions, how Streptomyces react and adapt to osmotic stress is heavily understudied. This is likely due to their complex developmental biology and an exceptionally broad number of signal transduction systems.With this review, we provide an overview of Streptomyces' responses to osmotic stress signals and draw attention to open questions in this research area.We discuss putative osmolyte transport systems that are likely involved in ion balance control and osmoadaptation and the role of alternative sigma factors and two-component systems (TCS) in osmoregulation. Finally, we highlight the current view on the role of the second messenger c-di-AMP in cell differentiation and the osmotic stress responses with specific emphasis on the two models, S. coelicolor and S. venezuelae.
AB - Streptomyces are prolific antibiotic producers that thrive in soil, where they encounter diverse environmental cues, including osmotic challenges caused by rainfall and drought. Despite their enormous value in the biotechnology sector, which often relies on ideal growth conditions, how Streptomyces react and adapt to osmotic stress is heavily understudied. This is likely due to their complex developmental biology and an exceptionally broad number of signal transduction systems.With this review, we provide an overview of Streptomyces' responses to osmotic stress signals and draw attention to open questions in this research area.We discuss putative osmolyte transport systems that are likely involved in ion balance control and osmoadaptation and the role of alternative sigma factors and two-component systems (TCS) in osmoregulation. Finally, we highlight the current view on the role of the second messenger c-di-AMP in cell differentiation and the osmotic stress responses with specific emphasis on the two models, S. coelicolor and S. venezuelae.
KW - AtaC
KW - DisA
KW - Streptomyces
KW - c-di-AMP
KW - osmotic stress
UR - http://www.scopus.com/inward/record.url?scp=85175186911&partnerID=8YFLogxK
U2 - 10.1093/femsml/uqad020
DO - 10.1093/femsml/uqad020
M3 - Article
VL - 4
JO - Microlife
JF - Microlife
M1 - uqad020
ER -