Details
| Original language | English |
|---|---|
| Pages (from-to) | 596-599 |
| Number of pages | 4 |
| Journal | Biomedizinische Technik |
| Volume | 57 |
| Issue number | SUPPL. 1 TRACK-D |
| Publication status | Published - 27 Aug 2012 |
Abstract
If blood pumps are applied in the human body or extracorporeal, blood damage can be caused by shear forces that act on the blood during the delivery. For an accelerated development of blood pumps with help of simulations there is a need for reliable limit values for shear forces. To determine these limit values a shear force test setup was built at the Institute for Multiphase Processes. In the context of the presented master thesis the former test setup peripheral devices were evaluated, possible blood damage mechanisms were considered, blood analysis in different experiments to identify the blood damage caused by different elements were made and peripheral devices were replaced. At the same time the shear chamber was constructional reengineered in a project thesis [1]. We were able to show, that in former works the blood damage caused by test setup peripheral devices had heterodyned the results. Finally the test setup was rebuilt with the results and a test was made. Two findings of the thesis are a reduction of about 60% of the number of components in the blood-conveying tube system and an application of a new fluid seal.
ASJC Scopus subject areas
- Engineering(all)
- Biomedical Engineering
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In: Biomedizinische Technik, Vol. 57, No. SUPPL. 1 TRACK-D, 27.08.2012, p. 596-599.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Optimization of a test setup for examining blood damage caused by high shear forces
AU - Kortlepel, R.
AU - Krolitzki, B.
AU - Müller, M.
AU - Glasmacher, B.
N1 - This work is partially funded by the German Research Foundation (SFB-TR37 -Q2 and B4)and the cluster of excellence REBIRTH (EXC 62/1).
PY - 2012/8/27
Y1 - 2012/8/27
N2 - If blood pumps are applied in the human body or extracorporeal, blood damage can be caused by shear forces that act on the blood during the delivery. For an accelerated development of blood pumps with help of simulations there is a need for reliable limit values for shear forces. To determine these limit values a shear force test setup was built at the Institute for Multiphase Processes. In the context of the presented master thesis the former test setup peripheral devices were evaluated, possible blood damage mechanisms were considered, blood analysis in different experiments to identify the blood damage caused by different elements were made and peripheral devices were replaced. At the same time the shear chamber was constructional reengineered in a project thesis [1]. We were able to show, that in former works the blood damage caused by test setup peripheral devices had heterodyned the results. Finally the test setup was rebuilt with the results and a test was made. Two findings of the thesis are a reduction of about 60% of the number of components in the blood-conveying tube system and an application of a new fluid seal.
AB - If blood pumps are applied in the human body or extracorporeal, blood damage can be caused by shear forces that act on the blood during the delivery. For an accelerated development of blood pumps with help of simulations there is a need for reliable limit values for shear forces. To determine these limit values a shear force test setup was built at the Institute for Multiphase Processes. In the context of the presented master thesis the former test setup peripheral devices were evaluated, possible blood damage mechanisms were considered, blood analysis in different experiments to identify the blood damage caused by different elements were made and peripheral devices were replaced. At the same time the shear chamber was constructional reengineered in a project thesis [1]. We were able to show, that in former works the blood damage caused by test setup peripheral devices had heterodyned the results. Finally the test setup was rebuilt with the results and a test was made. Two findings of the thesis are a reduction of about 60% of the number of components in the blood-conveying tube system and an application of a new fluid seal.
UR - http://www.scopus.com/inward/record.url?scp=84904001713&partnerID=8YFLogxK
U2 - 10.1515/bmt-2012-4362
DO - 10.1515/bmt-2012-4362
M3 - Article
AN - SCOPUS:84904001713
VL - 57
SP - 596
EP - 599
JO - Biomedizinische Technik
JF - Biomedizinische Technik
SN - 0013-5585
IS - SUPPL. 1 TRACK-D
ER -