Details
| Original language | English |
|---|---|
| Pages (from-to) | 71-77 |
| Number of pages | 7 |
| Journal | Sensors and Actuators, B: Chemical |
| Volume | 40 |
| Issue number | 1 |
| Publication status | Published - 1 May 1997 |
Abstract
The development of pH-based fibre-optic biosensors for penicillin, urea, creatinin and glucose and their uses in clinical applications are described. A simple but very efficient way of constructing biosensors is to immobilize an enzyme layer directly on the tip of a pH optode. Biosensors based on pH probes depend on critical factors such as the pH value and buffer ion concentration in the sample media. Since biosensors cannot be sterilized due to the instability of the biological component, they are normally integrated into flow-injection-analysis (FIA) systems. The complex signal is transformed and analysed by a computer system. Characteristic features of the FIA peak give information about the buffer capacity in the solution. With the help of intelligent computing (neural networks), it is possible to recognize these features and relate them to the respective buffer capacity to obtain more accurate values.
Keywords
- Biosensors, Flow-injection analysis, Neural networks, Optodes
ASJC Scopus subject areas
- Materials Science(all)
- Electronic, Optical and Magnetic Materials
- Physics and Astronomy(all)
- Instrumentation
- Physics and Astronomy(all)
- Condensed Matter Physics
- Materials Science(all)
- Surfaces, Coatings and Films
- Materials Science(all)
- Metals and Alloys
- Engineering(all)
- Electrical and Electronic Engineering
- Materials Science(all)
- Materials Chemistry
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In: Sensors and Actuators, B: Chemical, Vol. 40, No. 1, 01.05.1997, p. 71-77.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Optical chemo- and biosensors for use in clinical applications
AU - Müller, Cord
AU - Hitzmann, Bernd
AU - Schubert, Florian
AU - Scheper, Thomas
PY - 1997/5/1
Y1 - 1997/5/1
N2 - The development of pH-based fibre-optic biosensors for penicillin, urea, creatinin and glucose and their uses in clinical applications are described. A simple but very efficient way of constructing biosensors is to immobilize an enzyme layer directly on the tip of a pH optode. Biosensors based on pH probes depend on critical factors such as the pH value and buffer ion concentration in the sample media. Since biosensors cannot be sterilized due to the instability of the biological component, they are normally integrated into flow-injection-analysis (FIA) systems. The complex signal is transformed and analysed by a computer system. Characteristic features of the FIA peak give information about the buffer capacity in the solution. With the help of intelligent computing (neural networks), it is possible to recognize these features and relate them to the respective buffer capacity to obtain more accurate values.
AB - The development of pH-based fibre-optic biosensors for penicillin, urea, creatinin and glucose and their uses in clinical applications are described. A simple but very efficient way of constructing biosensors is to immobilize an enzyme layer directly on the tip of a pH optode. Biosensors based on pH probes depend on critical factors such as the pH value and buffer ion concentration in the sample media. Since biosensors cannot be sterilized due to the instability of the biological component, they are normally integrated into flow-injection-analysis (FIA) systems. The complex signal is transformed and analysed by a computer system. Characteristic features of the FIA peak give information about the buffer capacity in the solution. With the help of intelligent computing (neural networks), it is possible to recognize these features and relate them to the respective buffer capacity to obtain more accurate values.
KW - Biosensors
KW - Flow-injection analysis
KW - Neural networks
KW - Optodes
UR - http://www.scopus.com/inward/record.url?scp=0031131390&partnerID=8YFLogxK
U2 - 10.1016/S0925-4005(97)00016-6
DO - 10.1016/S0925-4005(97)00016-6
M3 - Article
AN - SCOPUS:0031131390
VL - 40
SP - 71
EP - 77
JO - Sensors and Actuators, B: Chemical
JF - Sensors and Actuators, B: Chemical
SN - 0925-4005
IS - 1
ER -