Details
| Original language | English |
|---|---|
| Pages (from-to) | 406-414 |
| Number of pages | 9 |
| Journal | Trends in biotechnology |
| Volume | 31 |
| Issue number | 7 |
| Publication status | Published - 23 May 2013 |
Abstract
Large cultivations of microalgae will benefit from on-line monitoring to achieve process control and improved productivity. This monitoring requires reliable sensors for on-line, in situ measurement of both physicochemical and biological process variables. Although standard industrial sensors can be used for many physicochemical variables, monitoring methods for most biological quantities rely on sensors that are currently suitable only for laboratory scale or off-line use. Here, we review these methods and discuss new approaches that could be adapted. We suggest that these new methods should be noninvasive and based on approaches that have already been applied to other bioprocesses; examples discussed here are in situ microscopy, flow cytometry (FC), IR spectroscopy, and software sensors.
Keywords
- Bioprocess monitoring, In situ microscopy, Microalgal cultivation, Optical sensors
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Biotechnology
- Chemical Engineering(all)
- Bioengineering
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In: Trends in biotechnology, Vol. 31, No. 7, 23.05.2013, p. 406-414.
Research output: Contribution to journal › Review article › Research › peer review
}
TY - JOUR
T1 - On-line monitoring of large cultivations of microalgae and cyanobacteria
AU - Havlik, Ivo
AU - Lindner, Patrick
AU - Scheper, Thomas
AU - Reardon, Kenneth F.
N1 - Funding information: This work was supported by the Sustainable Bioenergy Development Center of Colorado State University.
PY - 2013/5/23
Y1 - 2013/5/23
N2 - Large cultivations of microalgae will benefit from on-line monitoring to achieve process control and improved productivity. This monitoring requires reliable sensors for on-line, in situ measurement of both physicochemical and biological process variables. Although standard industrial sensors can be used for many physicochemical variables, monitoring methods for most biological quantities rely on sensors that are currently suitable only for laboratory scale or off-line use. Here, we review these methods and discuss new approaches that could be adapted. We suggest that these new methods should be noninvasive and based on approaches that have already been applied to other bioprocesses; examples discussed here are in situ microscopy, flow cytometry (FC), IR spectroscopy, and software sensors.
AB - Large cultivations of microalgae will benefit from on-line monitoring to achieve process control and improved productivity. This monitoring requires reliable sensors for on-line, in situ measurement of both physicochemical and biological process variables. Although standard industrial sensors can be used for many physicochemical variables, monitoring methods for most biological quantities rely on sensors that are currently suitable only for laboratory scale or off-line use. Here, we review these methods and discuss new approaches that could be adapted. We suggest that these new methods should be noninvasive and based on approaches that have already been applied to other bioprocesses; examples discussed here are in situ microscopy, flow cytometry (FC), IR spectroscopy, and software sensors.
KW - Bioprocess monitoring
KW - In situ microscopy
KW - Microalgal cultivation
KW - Optical sensors
UR - http://www.scopus.com/inward/record.url?scp=84879253492&partnerID=8YFLogxK
U2 - 10.1016/j.tibtech.2013.04.005
DO - 10.1016/j.tibtech.2013.04.005
M3 - Review article
C2 - 23707058
AN - SCOPUS:84879253492
VL - 31
SP - 406
EP - 414
JO - Trends in biotechnology
JF - Trends in biotechnology
SN - 0167-7799
IS - 7
ER -