Details
| Original language | English |
|---|---|
| Pages (from-to) | 11-22 |
| Number of pages | 12 |
| Journal | Applied Microbiology and Biotechnology |
| Volume | 88 |
| Issue number | 1 |
| Publication status | Published - 22 Jul 2010 |
Abstract
One of the major aims of bioprocess engineering is the real-time monitoring of important process variables. This is the basis of precise process control and is essential for high productivity as well as the exact documentation of the overall production process. Infrared spectroscopy is a powerful analytical technique to analyze a wide variety of organic compounds. Thus, infrared sensors are ideal instruments for bioprocess monitoring. The sensors are non-invasive, have no time delay due to sensor response times, and have no influence on the bioprocess itself. No sampling is necessary, and several components can be analyzed simultaneously. In general, the direct monitoring of substrates, products, metabolites, as well as the biomass itself is possible. In this review article, insights are provided into the different applications of infrared spectroscopy for bioprocess monitoring and the complex data interpretation. Different analytical techniques are presented as well as example applications in different areas.
Keywords
- Bioprocess, Infrared spectroscopy, On-line measurement, On-line monitoring, Sensor
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Biotechnology
- Immunology and Microbiology(all)
- Applied Microbiology and Biotechnology
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In: Applied Microbiology and Biotechnology, Vol. 88, No. 1, 22.07.2010, p. 11-22.
Research output: Contribution to journal › Survey paper › Research › peer review
}
TY - JOUR
T1 - On-line infrared spectroscopy for bioprocess monitoring
AU - Landgrebe, Daniel
AU - Haake, Claas
AU - Höpfner, Tim
AU - Beutel, Sascha
AU - Hitzmann, Bernd
AU - Scheper, Thomas
AU - Rhiel, Martin
AU - Reardon, Kenneth F.
PY - 2010/7/22
Y1 - 2010/7/22
N2 - One of the major aims of bioprocess engineering is the real-time monitoring of important process variables. This is the basis of precise process control and is essential for high productivity as well as the exact documentation of the overall production process. Infrared spectroscopy is a powerful analytical technique to analyze a wide variety of organic compounds. Thus, infrared sensors are ideal instruments for bioprocess monitoring. The sensors are non-invasive, have no time delay due to sensor response times, and have no influence on the bioprocess itself. No sampling is necessary, and several components can be analyzed simultaneously. In general, the direct monitoring of substrates, products, metabolites, as well as the biomass itself is possible. In this review article, insights are provided into the different applications of infrared spectroscopy for bioprocess monitoring and the complex data interpretation. Different analytical techniques are presented as well as example applications in different areas.
AB - One of the major aims of bioprocess engineering is the real-time monitoring of important process variables. This is the basis of precise process control and is essential for high productivity as well as the exact documentation of the overall production process. Infrared spectroscopy is a powerful analytical technique to analyze a wide variety of organic compounds. Thus, infrared sensors are ideal instruments for bioprocess monitoring. The sensors are non-invasive, have no time delay due to sensor response times, and have no influence on the bioprocess itself. No sampling is necessary, and several components can be analyzed simultaneously. In general, the direct monitoring of substrates, products, metabolites, as well as the biomass itself is possible. In this review article, insights are provided into the different applications of infrared spectroscopy for bioprocess monitoring and the complex data interpretation. Different analytical techniques are presented as well as example applications in different areas.
KW - Bioprocess
KW - Infrared spectroscopy
KW - On-line measurement
KW - On-line monitoring
KW - Sensor
UR - http://www.scopus.com/inward/record.url?scp=77955852809&partnerID=8YFLogxK
U2 - 10.1007/s00253-010-2743-8
DO - 10.1007/s00253-010-2743-8
M3 - Survey paper
C2 - 20652240
AN - SCOPUS:77955852809
VL - 88
SP - 11
EP - 22
JO - Applied Microbiology and Biotechnology
JF - Applied Microbiology and Biotechnology
SN - 0175-7598
IS - 1
ER -