Details
| Original language | English |
|---|---|
| Article number | 1299 |
| Journal | Polymers |
| Volume | 10 |
| Issue number | 12 |
| Early online date | 23 Nov 2018 |
| Publication status | Published - Dec 2018 |
Abstract
To form modern materials with biomimic surfaces, the novel pathway for surface functionalization with specific ligands of well-known and widely used polyester-based rigid media was developed and optimized. Two types of material bases, namely, poly(lactic acid) and poly("-caprolactone), as well as two types of material design, e.g., supermacroporous matrices and nanoparticles (NPs), were modified via covalent attachment of preliminary oxidized polyvinylsaccharide poly(2-deoxy-N-methacryloylamido-D-glucose) (PMAG). This polymer, being highly biocompatible and bioinspired, was used to enhance hydrophilicity of the polymer surface and to provide the elevated concentration of reactive groups required for covalent binding of bioligands of choice. The specialties of the interaction of PMAG and its preliminary formed bioconjugates with a chemically activated polyester surface were studied and thoroughly discussed. The supermacroporous materials modified with cell adhesion motifs and Arg-Gly-Asp-containing peptide (RGD-peptide) were tested in the experiments on bone tissue engineering. In turn, the NPs were modified with bioligands ("self-peptide" or camel antibodies) to control their phagocytosis that can be important, for example, for the preparation of drug delivery systems.
Keywords
- Biofunctionalization, Bioligands, Cells adhesion, Nanoparticles for drug delivery, PCL, Phagocytosis, PLA, Polyesters, Polyvinylsaccharide, Scaffolds for bone tissue engineering
ASJC Scopus subject areas
- Chemistry(all)
- Materials Science(all)
- Polymers and Plastics
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In: Polymers, Vol. 10, No. 12, 1299, 12.2018.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Novel Pathway for Efficient Covalent Modification of Polyester Materials of Different Design to Prepare Biomimetic Surfaces
AU - Korzhikov-Vlakh, Viktor
AU - Averianov, Ilia
AU - Sinitsyna, Ekaterina
AU - Nashchekina, Yuliya
AU - Polyakov, Dmitry
AU - Guryanov, Ivan
AU - Lavrentieva, Antonina
AU - Raddatz, Lukas
AU - Korzhikova-Vlakh, Evgenia
AU - Scheper, Thomas
AU - Tennikova, Tatiana
N1 - Funding information: This research was funded by Russian Science Foundation, grant number 14-50-00069 (05-109).
PY - 2018/12
Y1 - 2018/12
N2 - To form modern materials with biomimic surfaces, the novel pathway for surface functionalization with specific ligands of well-known and widely used polyester-based rigid media was developed and optimized. Two types of material bases, namely, poly(lactic acid) and poly("-caprolactone), as well as two types of material design, e.g., supermacroporous matrices and nanoparticles (NPs), were modified via covalent attachment of preliminary oxidized polyvinylsaccharide poly(2-deoxy-N-methacryloylamido-D-glucose) (PMAG). This polymer, being highly biocompatible and bioinspired, was used to enhance hydrophilicity of the polymer surface and to provide the elevated concentration of reactive groups required for covalent binding of bioligands of choice. The specialties of the interaction of PMAG and its preliminary formed bioconjugates with a chemically activated polyester surface were studied and thoroughly discussed. The supermacroporous materials modified with cell adhesion motifs and Arg-Gly-Asp-containing peptide (RGD-peptide) were tested in the experiments on bone tissue engineering. In turn, the NPs were modified with bioligands ("self-peptide" or camel antibodies) to control their phagocytosis that can be important, for example, for the preparation of drug delivery systems.
AB - To form modern materials with biomimic surfaces, the novel pathway for surface functionalization with specific ligands of well-known and widely used polyester-based rigid media was developed and optimized. Two types of material bases, namely, poly(lactic acid) and poly("-caprolactone), as well as two types of material design, e.g., supermacroporous matrices and nanoparticles (NPs), were modified via covalent attachment of preliminary oxidized polyvinylsaccharide poly(2-deoxy-N-methacryloylamido-D-glucose) (PMAG). This polymer, being highly biocompatible and bioinspired, was used to enhance hydrophilicity of the polymer surface and to provide the elevated concentration of reactive groups required for covalent binding of bioligands of choice. The specialties of the interaction of PMAG and its preliminary formed bioconjugates with a chemically activated polyester surface were studied and thoroughly discussed. The supermacroporous materials modified with cell adhesion motifs and Arg-Gly-Asp-containing peptide (RGD-peptide) were tested in the experiments on bone tissue engineering. In turn, the NPs were modified with bioligands ("self-peptide" or camel antibodies) to control their phagocytosis that can be important, for example, for the preparation of drug delivery systems.
KW - Biofunctionalization
KW - Bioligands
KW - Cells adhesion
KW - Nanoparticles for drug delivery
KW - PCL
KW - Phagocytosis
KW - PLA
KW - Polyesters
KW - Polyvinylsaccharide
KW - Scaffolds for bone tissue engineering
UR - http://www.scopus.com/inward/record.url?scp=85057292339&partnerID=8YFLogxK
U2 - 10.3390/polym10121299
DO - 10.3390/polym10121299
M3 - Article
AN - SCOPUS:85057292339
VL - 10
JO - Polymers
JF - Polymers
SN - 2073-4360
IS - 12
M1 - 1299
ER -