Details
| Original language | English |
|---|---|
| Pages (from-to) | 10990-10998 |
| Number of pages | 9 |
| Journal | Journal of the American Chemical Society |
| Volume | 133 |
| Issue number | 28 |
| Publication status | Published - 20 Jul 2011 |
| Externally published | Yes |
Abstract
The biosynthesis of the fungal metabolite tenellin from Beauveria bassiana CBS110.25 was investigated in the presence of the epigenetic modifiers 5-azacytidine and suberoyl bis-hydroxamic acid and under conditions where individual genes from the tenellin biosynthetic gene cluster were silenced. Numerous new compounds were synthesized, indicating that the normal predominant biosynthesis of tenellin is just one outcome out of a diverse array of possible products. The structures of the products reveal key clues about the programming selectivities of the tenellin polyketide synthase.
ASJC Scopus subject areas
- Chemical Engineering(all)
- Catalysis
- Chemistry(all)
- Biochemistry, Genetics and Molecular Biology(all)
- Biochemistry
- Chemical Engineering(all)
- Colloid and Surface Chemistry
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In: Journal of the American Chemical Society, Vol. 133, No. 28, 20.07.2011, p. 10990-10998.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Nongenetic reprogramming of a fungal highly reducing polyketide synthase
AU - Yakasai, Ahmed A.
AU - Davison, Jack
AU - Wasil, Zahida
AU - Halo, Laura M.
AU - Butts, Craig P.
AU - Lazarus, Colin M.
AU - Bailey, Andrew M.
AU - Simpson, Thomas J.
AU - Cox, Russell J.
PY - 2011/7/20
Y1 - 2011/7/20
N2 - The biosynthesis of the fungal metabolite tenellin from Beauveria bassiana CBS110.25 was investigated in the presence of the epigenetic modifiers 5-azacytidine and suberoyl bis-hydroxamic acid and under conditions where individual genes from the tenellin biosynthetic gene cluster were silenced. Numerous new compounds were synthesized, indicating that the normal predominant biosynthesis of tenellin is just one outcome out of a diverse array of possible products. The structures of the products reveal key clues about the programming selectivities of the tenellin polyketide synthase.
AB - The biosynthesis of the fungal metabolite tenellin from Beauveria bassiana CBS110.25 was investigated in the presence of the epigenetic modifiers 5-azacytidine and suberoyl bis-hydroxamic acid and under conditions where individual genes from the tenellin biosynthetic gene cluster were silenced. Numerous new compounds were synthesized, indicating that the normal predominant biosynthesis of tenellin is just one outcome out of a diverse array of possible products. The structures of the products reveal key clues about the programming selectivities of the tenellin polyketide synthase.
UR - http://www.scopus.com/inward/record.url?scp=79960206966&partnerID=8YFLogxK
U2 - 10.1021/ja204200x
DO - 10.1021/ja204200x
M3 - Article
C2 - 21675761
AN - SCOPUS:79960206966
VL - 133
SP - 10990
EP - 10998
JO - Journal of the American Chemical Society
JF - Journal of the American Chemical Society
SN - 0002-7863
IS - 28
ER -