Details
| Original language | English |
|---|---|
| Title of host publication | Photonic Diagnosis and Treatment of Infections and Inflammatory Diseases II |
| Editors | Tianhong Dai, Jurgen Popp, Mei X. Wu |
| Publisher | SPIE |
| Number of pages | 10 |
| ISBN (electronic) | 9781510623682 |
| Publication status | Published - 7 Mar 2019 |
| Event | Photonic Diagnosis and Treatment of Infections and Inflammatory Diseases II 2019 - San Francisco, United States Duration: 4 Feb 2019 → 5 Feb 2019 |
Publication series
| Name | Proceedings of SPIE - The International Society for Optical Engineering |
|---|---|
| Volume | 10863 |
| ISSN (Print) | 0277-786X |
| ISSN (electronic) | 1996-756X |
Abstract
Optical systems have shown their potential in non-invasive medical diagnostics over the last years. While most imaging systems use information on wavelength or phase, e.g. OCT, in our approach we focus on the polarization properties of biotissue. We designed a Mueller matrix (MM) measurement setup for in vivo investigations on skin tissue. The MM describes the polarization-changing properties of a sample. Thus, it is possible to calculate the MM from images taken with different polarization states of the illuminating and the observed light. For medical application, an important requirement is that the process is fast to enable in vivo measurement, avoid motion artifacts, and reduce stress for patients. In our setup, we use a combination of two polarizers and four liquid crystal retarders to quickly change between polarization states. The system is able to measure the location dependent MM of a target for different wavelengths. It is designed for measurement in reflection mode, however, upon simple modifications, it can be used in transmission mode as well. One interesting field of application is diagnostics for inflammatory skin diseases. Here, for example, changes in the structure and concentration of collagen could provide diagnostically valuable information. We evaluated our system on different skin phantoms to investigate the diagnostic advantages compared to standard approaches. In the future, our system could be part of a non-contact dermatoscopic device and provide extra information for the physician.
Keywords
- Biomedical imaging, Dermatoscopy, Inflammatory skin disease, Mueller matrix, Skin targets
ASJC Scopus subject areas
- Materials Science(all)
- Electronic, Optical and Magnetic Materials
- Physics and Astronomy(all)
- Condensed Matter Physics
- Computer Science(all)
- Computer Science Applications
- Mathematics(all)
- Applied Mathematics
- Engineering(all)
- Electrical and Electronic Engineering
Cite this
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- Apa
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- BibTeX
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Photonic Diagnosis and Treatment of Infections and Inflammatory Diseases II. ed. / Tianhong Dai; Jurgen Popp; Mei X. Wu. SPIE, 2019. 1086307 (Proceedings of SPIE - The International Society for Optical Engineering; Vol. 10863).
Research output: Chapter in book/report/conference proceeding › Conference contribution › Research › peer review
}
TY - GEN
T1 - Non-contact fast Mueller matrix measurement system for investigation of inflammatory skin diseases
AU - Fricke, Dierk
AU - Maas, Stephan
AU - Jütte, Lennart
AU - Wollweber, Merve
AU - Roth, Bernhard
N1 - Funding Information: This project is funded by the Lower Saxony Ministry for Culture and Science (MWK) as part of the program Tailored Light.
PY - 2019/3/7
Y1 - 2019/3/7
N2 - Optical systems have shown their potential in non-invasive medical diagnostics over the last years. While most imaging systems use information on wavelength or phase, e.g. OCT, in our approach we focus on the polarization properties of biotissue. We designed a Mueller matrix (MM) measurement setup for in vivo investigations on skin tissue. The MM describes the polarization-changing properties of a sample. Thus, it is possible to calculate the MM from images taken with different polarization states of the illuminating and the observed light. For medical application, an important requirement is that the process is fast to enable in vivo measurement, avoid motion artifacts, and reduce stress for patients. In our setup, we use a combination of two polarizers and four liquid crystal retarders to quickly change between polarization states. The system is able to measure the location dependent MM of a target for different wavelengths. It is designed for measurement in reflection mode, however, upon simple modifications, it can be used in transmission mode as well. One interesting field of application is diagnostics for inflammatory skin diseases. Here, for example, changes in the structure and concentration of collagen could provide diagnostically valuable information. We evaluated our system on different skin phantoms to investigate the diagnostic advantages compared to standard approaches. In the future, our system could be part of a non-contact dermatoscopic device and provide extra information for the physician.
AB - Optical systems have shown their potential in non-invasive medical diagnostics over the last years. While most imaging systems use information on wavelength or phase, e.g. OCT, in our approach we focus on the polarization properties of biotissue. We designed a Mueller matrix (MM) measurement setup for in vivo investigations on skin tissue. The MM describes the polarization-changing properties of a sample. Thus, it is possible to calculate the MM from images taken with different polarization states of the illuminating and the observed light. For medical application, an important requirement is that the process is fast to enable in vivo measurement, avoid motion artifacts, and reduce stress for patients. In our setup, we use a combination of two polarizers and four liquid crystal retarders to quickly change between polarization states. The system is able to measure the location dependent MM of a target for different wavelengths. It is designed for measurement in reflection mode, however, upon simple modifications, it can be used in transmission mode as well. One interesting field of application is diagnostics for inflammatory skin diseases. Here, for example, changes in the structure and concentration of collagen could provide diagnostically valuable information. We evaluated our system on different skin phantoms to investigate the diagnostic advantages compared to standard approaches. In the future, our system could be part of a non-contact dermatoscopic device and provide extra information for the physician.
KW - Biomedical imaging
KW - Dermatoscopy
KW - Inflammatory skin disease
KW - Mueller matrix
KW - Skin targets
UR - http://www.scopus.com/inward/record.url?scp=85072184691&partnerID=8YFLogxK
U2 - 10.1117/12.2509766
DO - 10.1117/12.2509766
M3 - Conference contribution
AN - SCOPUS:85072184691
T3 - Proceedings of SPIE - The International Society for Optical Engineering
BT - Photonic Diagnosis and Treatment of Infections and Inflammatory Diseases II
A2 - Dai, Tianhong
A2 - Popp, Jurgen
A2 - Wu, Mei X.
PB - SPIE
T2 - Photonic Diagnosis and Treatment of Infections and Inflammatory Diseases II 2019
Y2 - 4 February 2019 through 5 February 2019
ER -