Details
| Original language | English |
|---|---|
| Title of host publication | Photonics in Dermatology and Plastic Surgery 2020 |
| Editors | Bernard Choi, Haishan Zeng |
| Publisher | SPIE |
| ISBN (electronic) | 9781510631854 |
| Publication status | Published - 19 Feb 2020 |
| Event | Photonics in Dermatology and Plastic Surgery 2020 - San Francisco, United States Duration: 1 Feb 2020 → 2 Feb 2020 |
Publication series
| Name | Progress in Biomedical Optics and Imaging - Proceedings of SPIE |
|---|---|
| Volume | 11211 |
| ISSN (Print) | 1605-7422 |
Abstract
The orientation and concentration of structures like collagen within biological tissues can provide valuable information, for example, in skin disease diagnostics. Polarimetry lends itself for non-destructive investigation in various fields of research and development ranging from medical diagnostics to production monitoring, among others. We report on a system for polarimetric measurement of versatile targets in reflection and transmission mode. It efficiently determines the Mueller matrix (MM) of a sample under study and is also suited for in vivo applications. Generally, the Mueller matrix Mm allows to calculate the Stokes vector So of the light interacting with a sample, containing all information on its polarization properties, through So = Mm Si where Si is the Stokes vector of the illuminating light. The Mueller matrix can be derived from images taken with different polarization states of illuminating and observed light. In our setup we use liquid crystal retarders to precisely control the polarization states of the light. This enables fast measurement of the orientation of structures with high spatial resolution. In a first example, we demonstrate the capability of our system by characterizing electrospun fiber tissue implants and measuring the degree of alignment and orientation of the fibers in reflection mode. The results lead us to a deeper understanding of the signals which we expect from structures like collagen in skin. We were able to derive a correlation between the properties of the tissue structures, the parameters for production and the MM information, for the first time. This was possible by suitable decomposition of the MM into submatrices of known physical interpretation. In this work we present our latest results and discuss the next steps towards in vivo application in dermatology or tissue implant.
Keywords
- Dermatology, In vivo Monitoring, Mueller Matrix measurement, Polarimetry, Tissue implant
ASJC Scopus subject areas
- Materials Science(all)
- Electronic, Optical and Magnetic Materials
- Materials Science(all)
- Biomaterials
- Physics and Astronomy(all)
- Atomic and Molecular Physics, and Optics
- Medicine(all)
- Radiology Nuclear Medicine and imaging
Cite this
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- Harvard
- Apa
- Vancouver
- BibTeX
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Photonics in Dermatology and Plastic Surgery 2020. ed. / Bernard Choi; Haishan Zeng. SPIE, 2020. 1121116 (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 11211).
Research output: Chapter in book/report/conference proceeding › Conference contribution › Research › peer review
}
TY - GEN
T1 - Non-contact fast Mueller matrix measurement system for investigation of bio-tissues
AU - Fricke, Dierk
AU - Becker, Alexander
AU - Jütte, Lennart
AU - Wollweber, Merve
AU - Glasmacher, Birgit
AU - Roth, Bernhard
N1 - Funding information: This project is funded by the Lower Saxony Ministry for Culture and Science (MWK) through the program Tailored Light and the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) under Germany’s Excellence Strategy within the Cluster of Excellence PhoenixD (EXC 2122, Project ID 390833453). The research project is also supported by the DFG in the framework of the Research Unit 2180 ”Graded Implants for Tendon-Bone Junctions”.
PY - 2020/2/19
Y1 - 2020/2/19
N2 - The orientation and concentration of structures like collagen within biological tissues can provide valuable information, for example, in skin disease diagnostics. Polarimetry lends itself for non-destructive investigation in various fields of research and development ranging from medical diagnostics to production monitoring, among others. We report on a system for polarimetric measurement of versatile targets in reflection and transmission mode. It efficiently determines the Mueller matrix (MM) of a sample under study and is also suited for in vivo applications. Generally, the Mueller matrix Mm allows to calculate the Stokes vector So of the light interacting with a sample, containing all information on its polarization properties, through So = Mm Si where Si is the Stokes vector of the illuminating light. The Mueller matrix can be derived from images taken with different polarization states of illuminating and observed light. In our setup we use liquid crystal retarders to precisely control the polarization states of the light. This enables fast measurement of the orientation of structures with high spatial resolution. In a first example, we demonstrate the capability of our system by characterizing electrospun fiber tissue implants and measuring the degree of alignment and orientation of the fibers in reflection mode. The results lead us to a deeper understanding of the signals which we expect from structures like collagen in skin. We were able to derive a correlation between the properties of the tissue structures, the parameters for production and the MM information, for the first time. This was possible by suitable decomposition of the MM into submatrices of known physical interpretation. In this work we present our latest results and discuss the next steps towards in vivo application in dermatology or tissue implant.
AB - The orientation and concentration of structures like collagen within biological tissues can provide valuable information, for example, in skin disease diagnostics. Polarimetry lends itself for non-destructive investigation in various fields of research and development ranging from medical diagnostics to production monitoring, among others. We report on a system for polarimetric measurement of versatile targets in reflection and transmission mode. It efficiently determines the Mueller matrix (MM) of a sample under study and is also suited for in vivo applications. Generally, the Mueller matrix Mm allows to calculate the Stokes vector So of the light interacting with a sample, containing all information on its polarization properties, through So = Mm Si where Si is the Stokes vector of the illuminating light. The Mueller matrix can be derived from images taken with different polarization states of illuminating and observed light. In our setup we use liquid crystal retarders to precisely control the polarization states of the light. This enables fast measurement of the orientation of structures with high spatial resolution. In a first example, we demonstrate the capability of our system by characterizing electrospun fiber tissue implants and measuring the degree of alignment and orientation of the fibers in reflection mode. The results lead us to a deeper understanding of the signals which we expect from structures like collagen in skin. We were able to derive a correlation between the properties of the tissue structures, the parameters for production and the MM information, for the first time. This was possible by suitable decomposition of the MM into submatrices of known physical interpretation. In this work we present our latest results and discuss the next steps towards in vivo application in dermatology or tissue implant.
KW - Dermatology
KW - In vivo Monitoring
KW - Mueller Matrix measurement
KW - Polarimetry
KW - Tissue implant
UR - http://www.scopus.com/inward/record.url?scp=85081580227&partnerID=8YFLogxK
U2 - 10.1117/12.2559623
DO - 10.1117/12.2559623
M3 - Conference contribution
AN - SCOPUS:85081580227
T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE
BT - Photonics in Dermatology and Plastic Surgery 2020
A2 - Choi, Bernard
A2 - Zeng, Haishan
PB - SPIE
T2 - Photonics in Dermatology and Plastic Surgery 2020
Y2 - 1 February 2020 through 2 February 2020
ER -