Details
| Original language | English |
|---|---|
| Article number | e202400197 |
| Number of pages | 15 |
| Journal | CHEMISTRYOPEN |
| Volume | 13 |
| Issue number | 12 |
| Publication status | Published - 8 Dec 2024 |
Abstract
A number of new deoxyvasicinone (2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one) and mackinazolinone (6,7,8,9-tetrahydro-11H-pyrido[2,1-b]quinazolin-11-one) derivatives with aryl substituents at C7/C8 and at C5 are reported. These compounds are rare representatives of their kind and were prepared in high yields by Suzuki-Miyaura cross-coupling reactions between 7-bromo-2,3-dihydro[2,1-b]quinazoline-9-(1H)-one, 5,7-dibromo-2,3-dihydro[2,1-b]quinazoline-9-(1H)-one or 8-bromomackinazolinone and respective arylboronic acids with palladium acetate as the catalyst. The products were characterized spectroscopically and, in addition, by X-ray crystal structure analyses in six cases.
Keywords
- Cross-Coupling, Palladium Catalysis, Quinazoline, Suzuki-Miyaura Reaction
ASJC Scopus subject areas
- Chemistry(all)
- General Chemistry
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In: CHEMISTRYOPEN, Vol. 13, No. 12, e202400197, 08.12.2024.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - New Tricyclic Aryl Quinazoline Derivatives by Suzuki-Miyaura Cross-Coupling
AU - Elmuradov, Burkhon
AU - Okmanov, Rasul
AU - Juraev, Bakhromjon
AU - Dräger, Gerald
AU - Butenschön, Holger
N1 - Publisher Copyright: © 2024 The Authors. ChemistryOpen published by Wiley-VCH GmbH.
PY - 2024/12/8
Y1 - 2024/12/8
N2 - A number of new deoxyvasicinone (2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one) and mackinazolinone (6,7,8,9-tetrahydro-11H-pyrido[2,1-b]quinazolin-11-one) derivatives with aryl substituents at C7/C8 and at C5 are reported. These compounds are rare representatives of their kind and were prepared in high yields by Suzuki-Miyaura cross-coupling reactions between 7-bromo-2,3-dihydro[2,1-b]quinazoline-9-(1H)-one, 5,7-dibromo-2,3-dihydro[2,1-b]quinazoline-9-(1H)-one or 8-bromomackinazolinone and respective arylboronic acids with palladium acetate as the catalyst. The products were characterized spectroscopically and, in addition, by X-ray crystal structure analyses in six cases.
AB - A number of new deoxyvasicinone (2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one) and mackinazolinone (6,7,8,9-tetrahydro-11H-pyrido[2,1-b]quinazolin-11-one) derivatives with aryl substituents at C7/C8 and at C5 are reported. These compounds are rare representatives of their kind and were prepared in high yields by Suzuki-Miyaura cross-coupling reactions between 7-bromo-2,3-dihydro[2,1-b]quinazoline-9-(1H)-one, 5,7-dibromo-2,3-dihydro[2,1-b]quinazoline-9-(1H)-one or 8-bromomackinazolinone and respective arylboronic acids with palladium acetate as the catalyst. The products were characterized spectroscopically and, in addition, by X-ray crystal structure analyses in six cases.
KW - Cross-Coupling
KW - Palladium Catalysis
KW - Quinazoline
KW - Suzuki-Miyaura Reaction
UR - http://www.scopus.com/inward/record.url?scp=85205041343&partnerID=8YFLogxK
U2 - 10.1002/open.202400197
DO - 10.1002/open.202400197
M3 - Article
AN - SCOPUS:85205041343
VL - 13
JO - CHEMISTRYOPEN
JF - CHEMISTRYOPEN
SN - 2191-1363
IS - 12
M1 - e202400197
ER -