Details
| Original language | English |
|---|---|
| Journal | INTERFACE FOCUS |
| Volume | 3 |
| Issue number | 2 |
| Publication status | Published - 6 Apr 2013 |
Abstract
Personalized medicine relies in part upon comprehensive data on patient treatment and outcomes, both for analysis leading to improved models that provide the basis for enhanced treatment, and for direct use in clinical decision-making. A data warehouse is an information technology for combining and standardizing multiple databases. Data warehousing of clinical data is constrained by many legal and ethical considerations, owing to the sensitive nature of the data being stored.We describe an unconstrained clinical data warehousing architecture, some of the legal constraints that have led us to reconsider this architecture, and the legal and technical solutions to these constraints developed for the clinical data warehouse in the personalized medicine project p-medicine.We also propose some changes to the legal constraints that will further enable clinical research.
Keywords
- Clinical data warehouse, Legal and ethical constraints, Personalized medicine
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Biotechnology
- Biochemistry, Genetics and Molecular Biology(all)
- Biophysics
- Chemical Engineering(all)
- Bioengineering
- Biochemistry, Genetics and Molecular Biology(all)
- Biochemistry
- Materials Science(all)
- Biomaterials
- Engineering(all)
- Biomedical Engineering
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In: INTERFACE FOCUS, Vol. 3, No. 2, 06.04.2013.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Navigating legal constraints in clinical data warehousing
T2 - A case study in personalized medicine
AU - Jefferys, Benjamin R.
AU - Nwankwo, Iheanyi
AU - Neri, Elias
AU - Chang, David C.W.
AU - Shamardin, Lev
AU - Hänold, Stefanie
AU - Graf, Norbert
AU - Forgó, Nikolaus
AU - Coveney, Peter
PY - 2013/4/6
Y1 - 2013/4/6
N2 - Personalized medicine relies in part upon comprehensive data on patient treatment and outcomes, both for analysis leading to improved models that provide the basis for enhanced treatment, and for direct use in clinical decision-making. A data warehouse is an information technology for combining and standardizing multiple databases. Data warehousing of clinical data is constrained by many legal and ethical considerations, owing to the sensitive nature of the data being stored.We describe an unconstrained clinical data warehousing architecture, some of the legal constraints that have led us to reconsider this architecture, and the legal and technical solutions to these constraints developed for the clinical data warehouse in the personalized medicine project p-medicine.We also propose some changes to the legal constraints that will further enable clinical research.
AB - Personalized medicine relies in part upon comprehensive data on patient treatment and outcomes, both for analysis leading to improved models that provide the basis for enhanced treatment, and for direct use in clinical decision-making. A data warehouse is an information technology for combining and standardizing multiple databases. Data warehousing of clinical data is constrained by many legal and ethical considerations, owing to the sensitive nature of the data being stored.We describe an unconstrained clinical data warehousing architecture, some of the legal constraints that have led us to reconsider this architecture, and the legal and technical solutions to these constraints developed for the clinical data warehouse in the personalized medicine project p-medicine.We also propose some changes to the legal constraints that will further enable clinical research.
KW - Clinical data warehouse
KW - Legal and ethical constraints
KW - Personalized medicine
UR - http://www.scopus.com/inward/record.url?scp=84875409209&partnerID=8YFLogxK
U2 - 10.1098/rsfs.2012.0088
DO - 10.1098/rsfs.2012.0088
M3 - Article
AN - SCOPUS:84875409209
VL - 3
JO - INTERFACE FOCUS
JF - INTERFACE FOCUS
SN - 2042-8898
IS - 2
ER -