Details
| Original language | English |
|---|---|
| Pages (from-to) | 1080-1097 |
| Number of pages | 18 |
| Journal | Natural Product Reports |
| Volume | 37 |
| Issue number | 8 |
| Publication status | Published - 18 Feb 2020 |
Abstract
Covering: up to 2019The reactions catalysed by terpene synthases belong to the most complex and fascinating cascade-type transformations in Nature. Although many accept only one natural terpene precursor and convert it with high selectivity into only one product, several of these remarkable biocatalysts were recently shown to have a surprising plasticity towards non-natural substrate analogues. For an easy access to the topic also for readers who are new to the field, this review will first briefly cover the principles of natural terpene biosynthesis. This is followed by a chapter that highlights purely chemical transformations mimicking terpene synthase catalysed reactions. Then, the main focus of this article will shed light on the recent advances of terpene synthase catalysed transformations of synthetic substrate analogues. As will be demonstrated, a simple conceptual approach extensively broadens the chemical space that can be reached with terpene synthases.
ASJC Scopus subject areas
- Pharmacology, Toxicology and Pharmaceutics(all)
- Drug Discovery
- Biochemistry, Genetics and Molecular Biology(all)
- Biochemistry
- Chemistry(all)
- Organic Chemistry
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In: Natural Product Reports, Vol. 37, No. 8, 18.02.2020, p. 1080-1097.
Research output: Contribution to journal › Article › Research
}
TY - JOUR
T1 - Nature-driven approaches to non-natural terpene analogues
AU - Harms, Vanessa
AU - Kirschning, Andreas
AU - Dickschat, Jeroen S.
PY - 2020/2/18
Y1 - 2020/2/18
N2 - Covering: up to 2019The reactions catalysed by terpene synthases belong to the most complex and fascinating cascade-type transformations in Nature. Although many accept only one natural terpene precursor and convert it with high selectivity into only one product, several of these remarkable biocatalysts were recently shown to have a surprising plasticity towards non-natural substrate analogues. For an easy access to the topic also for readers who are new to the field, this review will first briefly cover the principles of natural terpene biosynthesis. This is followed by a chapter that highlights purely chemical transformations mimicking terpene synthase catalysed reactions. Then, the main focus of this article will shed light on the recent advances of terpene synthase catalysed transformations of synthetic substrate analogues. As will be demonstrated, a simple conceptual approach extensively broadens the chemical space that can be reached with terpene synthases.
AB - Covering: up to 2019The reactions catalysed by terpene synthases belong to the most complex and fascinating cascade-type transformations in Nature. Although many accept only one natural terpene precursor and convert it with high selectivity into only one product, several of these remarkable biocatalysts were recently shown to have a surprising plasticity towards non-natural substrate analogues. For an easy access to the topic also for readers who are new to the field, this review will first briefly cover the principles of natural terpene biosynthesis. This is followed by a chapter that highlights purely chemical transformations mimicking terpene synthase catalysed reactions. Then, the main focus of this article will shed light on the recent advances of terpene synthase catalysed transformations of synthetic substrate analogues. As will be demonstrated, a simple conceptual approach extensively broadens the chemical space that can be reached with terpene synthases.
UR - http://www.scopus.com/inward/record.url?scp=85085759790&partnerID=8YFLogxK
U2 - 10.1039/c9np00055k
DO - 10.1039/c9np00055k
M3 - Article
C2 - 32068211
VL - 37
SP - 1080
EP - 1097
JO - Natural Product Reports
JF - Natural Product Reports
SN - 0265-0568
IS - 8
ER -