Details
| Original language | English |
|---|---|
| Pages (from-to) | 2490-2503 |
| Number of pages | 14 |
| Journal | Journal of the Chemical Society. Perkin Transactions 1 |
| Volume | 2 |
| Issue number | 22 |
| Publication status | Published - 17 Oct 2002 |
| Externally published | Yes |
Abstract
Novel and unique chiral building blocks of high structural diversity were obtained by selective chemical fragmentation of natural products from myxobacteria. Subsequent modification reactions provided primary alcohol and carboxylic acid derivatives, which are suitable for the construction of combinatorial chemical libraries. The single SPOT synthesis of a hybrid structure on a polypropylene membrane was employed to demonstrate the chemical recombination of such rare building blocks on a micro-scale.
ASJC Scopus subject areas
- Chemistry(all)
- General Chemistry
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In: Journal of the Chemical Society. Perkin Transactions 1, Vol. 2, No. 22, 17.10.2002, p. 2490-2503.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Natural product-derived building blocks for combinatorial synthesis. Part 1. Fragmentation of natural products from myxobacteria
AU - Niggemann, Jutta
AU - Michaelis, Katrin
AU - Frank, Ronald
AU - Zander, Norbert
AU - Höfle, Gerhard
PY - 2002/10/17
Y1 - 2002/10/17
N2 - Novel and unique chiral building blocks of high structural diversity were obtained by selective chemical fragmentation of natural products from myxobacteria. Subsequent modification reactions provided primary alcohol and carboxylic acid derivatives, which are suitable for the construction of combinatorial chemical libraries. The single SPOT synthesis of a hybrid structure on a polypropylene membrane was employed to demonstrate the chemical recombination of such rare building blocks on a micro-scale.
AB - Novel and unique chiral building blocks of high structural diversity were obtained by selective chemical fragmentation of natural products from myxobacteria. Subsequent modification reactions provided primary alcohol and carboxylic acid derivatives, which are suitable for the construction of combinatorial chemical libraries. The single SPOT synthesis of a hybrid structure on a polypropylene membrane was employed to demonstrate the chemical recombination of such rare building blocks on a micro-scale.
UR - http://www.scopus.com/inward/record.url?scp=0037159923&partnerID=8YFLogxK
U2 - 10.1039/b206953a
DO - 10.1039/b206953a
M3 - Article
AN - SCOPUS:0037159923
VL - 2
SP - 2490
EP - 2503
JO - Journal of the Chemical Society. Perkin Transactions 1
JF - Journal of the Chemical Society. Perkin Transactions 1
SN - 1472-7781
IS - 22
ER -