Details
| Original language | English |
|---|---|
| Pages (from-to) | 1210-1215 |
| Number of pages | 6 |
| Journal | Physica Status Solidi (A) Applications and Materials Science |
| Volume | 212 |
| Issue number | 6 |
| Publication status | Published - 30 Jan 2015 |
| Externally published | Yes |
Abstract
A cochlear implant is a surgically implanted device that helps to restore hearing for most severe hearing impaired patients. During the first 2-3 weeks after implantation of a cochlear implant electrode array, the electrical impedance at the electrode contacts increases. This increase is typically explained by the formation of fibrous tissue around the electrode array. To improve the electrode nerve interface in these patients, it is aimed at a reduction of tissue formation around the electrode array after implantation. Previously we have demonstrated that nanostructuring of platinum surfaces can inhibit fibroblast growth in vitro. In the current study we generated nanostructures directly on the surfaces of cochlear implant electrodes and tested their potential to reduce connective tissue formation around the electrode array in vivo by means of electrophysiological measurements. Guinea pigs were implanted with unstructured control or surface structured electrode arrays for 4 weeks. Impedance measurements were performed during the first 2 weeks daily, later weekly. Recorded impedances were typically lower for surface functionalized electrodes. Nanostructuring of the surface of the stimulating contacts of CI electrodes additionally resulted in a delayed increase in impedance showing that this modification has the potential for in vivo applications.
Keywords
- cochlear implants, electrode contacts, impedance, laser patterning, nanostructures
ASJC Scopus subject areas
- Materials Science(all)
- Electronic, Optical and Magnetic Materials
- Physics and Astronomy(all)
- Condensed Matter Physics
- Physics and Astronomy(all)
- Surfaces and Interfaces
- Materials Science(all)
- Surfaces, Coatings and Films
- Engineering(all)
- Electrical and Electronic Engineering
- Materials Science(all)
- Materials Chemistry
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In: Physica Status Solidi (A) Applications and Materials Science, Vol. 212, No. 6, 30.01.2015, p. 1210-1215.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Nanostructuring of cochlear implant electrode contacts induces delayed impedance increase in vivo
AU - Linke, Ines
AU - Fadeeva, Elena
AU - Scheper, Verena
AU - Esser, Karl Heinz
AU - Koch, Jürgen
AU - Chichkov, Boris N.
AU - Lenarz, Thomas
AU - Paasche, Gerrit
PY - 2015/1/30
Y1 - 2015/1/30
N2 - A cochlear implant is a surgically implanted device that helps to restore hearing for most severe hearing impaired patients. During the first 2-3 weeks after implantation of a cochlear implant electrode array, the electrical impedance at the electrode contacts increases. This increase is typically explained by the formation of fibrous tissue around the electrode array. To improve the electrode nerve interface in these patients, it is aimed at a reduction of tissue formation around the electrode array after implantation. Previously we have demonstrated that nanostructuring of platinum surfaces can inhibit fibroblast growth in vitro. In the current study we generated nanostructures directly on the surfaces of cochlear implant electrodes and tested their potential to reduce connective tissue formation around the electrode array in vivo by means of electrophysiological measurements. Guinea pigs were implanted with unstructured control or surface structured electrode arrays for 4 weeks. Impedance measurements were performed during the first 2 weeks daily, later weekly. Recorded impedances were typically lower for surface functionalized electrodes. Nanostructuring of the surface of the stimulating contacts of CI electrodes additionally resulted in a delayed increase in impedance showing that this modification has the potential for in vivo applications.
AB - A cochlear implant is a surgically implanted device that helps to restore hearing for most severe hearing impaired patients. During the first 2-3 weeks after implantation of a cochlear implant electrode array, the electrical impedance at the electrode contacts increases. This increase is typically explained by the formation of fibrous tissue around the electrode array. To improve the electrode nerve interface in these patients, it is aimed at a reduction of tissue formation around the electrode array after implantation. Previously we have demonstrated that nanostructuring of platinum surfaces can inhibit fibroblast growth in vitro. In the current study we generated nanostructures directly on the surfaces of cochlear implant electrodes and tested their potential to reduce connective tissue formation around the electrode array in vivo by means of electrophysiological measurements. Guinea pigs were implanted with unstructured control or surface structured electrode arrays for 4 weeks. Impedance measurements were performed during the first 2 weeks daily, later weekly. Recorded impedances were typically lower for surface functionalized electrodes. Nanostructuring of the surface of the stimulating contacts of CI electrodes additionally resulted in a delayed increase in impedance showing that this modification has the potential for in vivo applications.
KW - cochlear implants
KW - electrode contacts
KW - impedance
KW - laser patterning
KW - nanostructures
UR - http://www.scopus.com/inward/record.url?scp=84934975948&partnerID=8YFLogxK
U2 - 10.1002/pssa.201431746
DO - 10.1002/pssa.201431746
M3 - Article
AN - SCOPUS:84934975948
VL - 212
SP - 1210
EP - 1215
JO - Physica Status Solidi (A) Applications and Materials Science
JF - Physica Status Solidi (A) Applications and Materials Science
SN - 1862-6300
IS - 6
ER -