Details
| Translated title of the contribution | Food supplements - Possibilities and limitations: Part 6, safety and possible risks |
|---|---|
| Original language | German |
| Pages (from-to) | 249-256 |
| Number of pages | 8 |
| Journal | Medizinische Monatsschrift fur Pharmazeuten |
| Volume | 37 |
| Issue number | 7 |
| Publication status | Published - Jul 2014 |
Abstract
Due to the precautionary principle in consumer protection, thresholds for long-term safety of nutrients have to be defined. Three toxical indicators are of interest: lowest observed adverse effect level (LOAEL); no observed adverse effect level (NOAEL) und tolerable level of upper intake (UL). An uptake of a nutrient within the range of UL is without side effects even on the basis of long term consumption. The UL can be used to derive maximum levels for nutrients in food supplements. In general, vitamins can be regarded as safe nutrients except for vitamin A. Adverse effects only occur at excessive intake far beyond the recommended daily allowances. In contrast, the range of safe intake for minerals, especially trace elements, is much smaller. This can be seen clearly in the case of selenium. In order to prevent severe selenium deficiency a plasma concentration of > 0.25 μmol/l (> 20 μg/l) must be reached. To minimize cancer risk a plasma concentration of 1.5 μmol/l (120?μg/l) is needed. First signs of selenium intoxications occur at plasma levels over 250 μg/l. It is the dose that makes the preventive effect and the poison as well.
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In: Medizinische Monatsschrift fur Pharmazeuten, Vol. 37, No. 7, 07.2014, p. 249-256.
Research output: Contribution to journal › Article › Research
}
TY - JOUR
T1 - Nährstoffsupplemente - Möglichkeiten und Grenzen. Teil 6: Sicherheit und mögliche Risiken
AU - Ströhle, A.
AU - Hahn, A.
N1 - Copyright: Copyright 2014 Elsevier B.V., All rights reserved.
PY - 2014/7
Y1 - 2014/7
N2 - Due to the precautionary principle in consumer protection, thresholds for long-term safety of nutrients have to be defined. Three toxical indicators are of interest: lowest observed adverse effect level (LOAEL); no observed adverse effect level (NOAEL) und tolerable level of upper intake (UL). An uptake of a nutrient within the range of UL is without side effects even on the basis of long term consumption. The UL can be used to derive maximum levels for nutrients in food supplements. In general, vitamins can be regarded as safe nutrients except for vitamin A. Adverse effects only occur at excessive intake far beyond the recommended daily allowances. In contrast, the range of safe intake for minerals, especially trace elements, is much smaller. This can be seen clearly in the case of selenium. In order to prevent severe selenium deficiency a plasma concentration of > 0.25 μmol/l (> 20 μg/l) must be reached. To minimize cancer risk a plasma concentration of 1.5 μmol/l (120?μg/l) is needed. First signs of selenium intoxications occur at plasma levels over 250 μg/l. It is the dose that makes the preventive effect and the poison as well.
AB - Due to the precautionary principle in consumer protection, thresholds for long-term safety of nutrients have to be defined. Three toxical indicators are of interest: lowest observed adverse effect level (LOAEL); no observed adverse effect level (NOAEL) und tolerable level of upper intake (UL). An uptake of a nutrient within the range of UL is without side effects even on the basis of long term consumption. The UL can be used to derive maximum levels for nutrients in food supplements. In general, vitamins can be regarded as safe nutrients except for vitamin A. Adverse effects only occur at excessive intake far beyond the recommended daily allowances. In contrast, the range of safe intake for minerals, especially trace elements, is much smaller. This can be seen clearly in the case of selenium. In order to prevent severe selenium deficiency a plasma concentration of > 0.25 μmol/l (> 20 μg/l) must be reached. To minimize cancer risk a plasma concentration of 1.5 μmol/l (120?μg/l) is needed. First signs of selenium intoxications occur at plasma levels over 250 μg/l. It is the dose that makes the preventive effect and the poison as well.
UR - http://www.scopus.com/inward/record.url?scp=84904267435&partnerID=8YFLogxK
M3 - Artikel
VL - 37
SP - 249
EP - 256
JO - Medizinische Monatsschrift fur Pharmazeuten
JF - Medizinische Monatsschrift fur Pharmazeuten
SN - 0342-9601
IS - 7
ER -