Multiphoton microscopy of transdermal quantum dot delivery using two photon polymerization-fabricated polymer microneedles

Research output: Contribution to journal › Article › Research › peer review

Authors

  • Shaun D. Gittard
  • Philip R. Miller
  • Ryan D. Boehm
  • Aleksandr Ovsianikov
  • Boris N. Chichkov
  • Jeremy Heiser
  • John Gordon
  • Nancy A. Monteiro-Riviere
  • Roger J. Narayan

External Research Organisations

  • North Carolina State University
  • Laser Zentrum Hannover e.V. (LZH)
  • Ceramatec Inc.
  • MicroLin LLC and Technology Holding LLC
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Details

Original languageEnglish
Pages (from-to)171-185
Number of pages15
JournalFaraday discussions
Volume149
Publication statusPublished - 2011
Externally publishedYes

Abstract

Due to their ability to serve as fluorophores and drug delivery vehicles, quantum dots are a powerful tool for theranostics-based clinical applications. In this study, microneedle devices for transdermal drug delivery were fabricated by means of two-photon polymerization of an acrylate-based polymer. We examined proliferation of cells on this polymer using neonatal human epidermal keratinocytes and human dermal fibroblasts. The microneedle device was used to inject quantum dots into porcine skin; imaging of the quantum dots was performed using multiphoton microscopy.

ASJC Scopus subject areas

Cite this

Multiphoton microscopy of transdermal quantum dot delivery using two photon polymerization-fabricated polymer microneedles. / Gittard, Shaun D.; Miller, Philip R.; Boehm, Ryan D. et al.
In: Faraday discussions, Vol. 149, 2011, p. 171-185.

Research output: Contribution to journal › Article › Research › peer review

Gittard, SD, Miller, PR, Boehm, RD, Ovsianikov, A, Chichkov, BN, Heiser, J, Gordon, J, Monteiro-Riviere, NA & Narayan, RJ 2011, 'Multiphoton microscopy of transdermal quantum dot delivery using two photon polymerization-fabricated polymer microneedles', Faraday discussions, vol. 149, pp. 171-185. https://doi.org/10.1039/c005374k
Gittard, S. D., Miller, P. R., Boehm, R. D., Ovsianikov, A., Chichkov, B. N., Heiser, J., Gordon, J., Monteiro-Riviere, N. A., & Narayan, R. J. (2011). Multiphoton microscopy of transdermal quantum dot delivery using two photon polymerization-fabricated polymer microneedles. Faraday discussions, 149, 171-185. https://doi.org/10.1039/c005374k
Gittard SD, Miller PR, Boehm RD, Ovsianikov A, Chichkov BN, Heiser J et al. Multiphoton microscopy of transdermal quantum dot delivery using two photon polymerization-fabricated polymer microneedles. Faraday discussions. 2011;149:171-185. doi: 10.1039/c005374k
Gittard, Shaun D. ; Miller, Philip R. ; Boehm, Ryan D. et al. / Multiphoton microscopy of transdermal quantum dot delivery using two photon polymerization-fabricated polymer microneedles. In: Faraday discussions. 2011 ; Vol. 149. pp. 171-185.
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