Details
| Original language | English |
|---|---|
| Title of host publication | Multimodal Biomedical Imaging XVIII |
| Editors | Fred S. Azar, Xavier Intes, Qianqian Fang |
| Publisher | SPIE |
| ISBN (electronic) | 9781510658479 |
| Publication status | Published - 6 Mar 2023 |
| Event | Multimodal Biomedical Imaging XVIII 2023 - San Francisco, United States Duration: 28 Jan 2023 → 3 Feb 2023 |
Publication series
| Name | Progress in Biomedical Optics and Imaging - Proceedings of SPIE |
|---|---|
| Volume | 12371 |
| ISSN (Print) | 1605-7422 |
Abstract
The rate of skin cancer incidence including melanoma has been steadily increasing in the last decades. While melanoma often show little to no symptoms in the early stages, they can spread to the lymph nodes and drastically reduce survival chances in the later stages. The current gold standard for diagnosis is visual examination, excision, and histological examination of the sample tissue, which is an invasive, costly and time-consuming process. As an alternative to this procedure, we introduce a novel multimodal optical system that integrates ultrasound (US), photoacoustic tomography (PAT), and optical coherence tomography (OCT) with Raman spectroscopy (RS). The setup allows quick and non-invasive skin lesion diagnosis and the determination of 3D lesion depth, helping the dermatologists make a decision on the excision margins. The OCT delivers structural and depth information of thin skin lesions, while the US and PAT measure the penetration depth of thicker lesions and the RS analyzes the chemical composition that can be used to distinguish between benign and malignant skin lesions. In our setup, the RS and OCT share the optical path and the scanning elements, which allows colocalized measurements. The US and PAT are integrated with an acoustical reflector, which enables B-mode measurements at the same position as OCT and RS without switching the scanning head. We demonstrate the imaging capabilities of the multimodal setup on custom made agar phantoms and present first measurements on ex vivo mouse and in vivo human skin samples. We compare the results with the corresponding histological images.
Keywords
- multimodal optical setup, optical coherence tomography, photoacoustic tomography, Raman spectroscopy, ultrasound tomography
ASJC Scopus subject areas
- Materials Science(all)
- Electronic, Optical and Magnetic Materials
- Physics and Astronomy(all)
- Atomic and Molecular Physics, and Optics
- Materials Science(all)
- Biomaterials
- Medicine(all)
- Radiology Nuclear Medicine and imaging
Sustainable Development Goals
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Multimodal Biomedical Imaging XVIII. ed. / Fred S. Azar; Xavier Intes; Qianqian Fang. SPIE, 2023. 1237107 (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 12371).
Research output: Chapter in book/report/conference proceeding › Conference contribution › Research › peer review
}
TY - GEN
T1 - Multimodal imaging system with ultrasound, photoacoustics, and optical coherence tomography for optical biopsy of melanoma
AU - Kukk, Anatoly Fedorov
AU - Wu, Di
AU - Gaffal, Evelyn
AU - Panzer, Rüdiger
AU - Emmert, Steffen
AU - Roth, Bernhard
N1 - Funding Information: The authors acknowledge financial support from the German Research Foundation DFG (German Research Foundation, Project ID RO 3471/18-1 and EM 63/13-1). Also, financial support from the German Research Foundation (DFG) under Germany’s Excellence Strategy within the Cluster of Excellence PhoenixD (EXC 2122, Project ID 390833453) is acknowledged.
PY - 2023/3/6
Y1 - 2023/3/6
N2 - The rate of skin cancer incidence including melanoma has been steadily increasing in the last decades. While melanoma often show little to no symptoms in the early stages, they can spread to the lymph nodes and drastically reduce survival chances in the later stages. The current gold standard for diagnosis is visual examination, excision, and histological examination of the sample tissue, which is an invasive, costly and time-consuming process. As an alternative to this procedure, we introduce a novel multimodal optical system that integrates ultrasound (US), photoacoustic tomography (PAT), and optical coherence tomography (OCT) with Raman spectroscopy (RS). The setup allows quick and non-invasive skin lesion diagnosis and the determination of 3D lesion depth, helping the dermatologists make a decision on the excision margins. The OCT delivers structural and depth information of thin skin lesions, while the US and PAT measure the penetration depth of thicker lesions and the RS analyzes the chemical composition that can be used to distinguish between benign and malignant skin lesions. In our setup, the RS and OCT share the optical path and the scanning elements, which allows colocalized measurements. The US and PAT are integrated with an acoustical reflector, which enables B-mode measurements at the same position as OCT and RS without switching the scanning head. We demonstrate the imaging capabilities of the multimodal setup on custom made agar phantoms and present first measurements on ex vivo mouse and in vivo human skin samples. We compare the results with the corresponding histological images.
AB - The rate of skin cancer incidence including melanoma has been steadily increasing in the last decades. While melanoma often show little to no symptoms in the early stages, they can spread to the lymph nodes and drastically reduce survival chances in the later stages. The current gold standard for diagnosis is visual examination, excision, and histological examination of the sample tissue, which is an invasive, costly and time-consuming process. As an alternative to this procedure, we introduce a novel multimodal optical system that integrates ultrasound (US), photoacoustic tomography (PAT), and optical coherence tomography (OCT) with Raman spectroscopy (RS). The setup allows quick and non-invasive skin lesion diagnosis and the determination of 3D lesion depth, helping the dermatologists make a decision on the excision margins. The OCT delivers structural and depth information of thin skin lesions, while the US and PAT measure the penetration depth of thicker lesions and the RS analyzes the chemical composition that can be used to distinguish between benign and malignant skin lesions. In our setup, the RS and OCT share the optical path and the scanning elements, which allows colocalized measurements. The US and PAT are integrated with an acoustical reflector, which enables B-mode measurements at the same position as OCT and RS without switching the scanning head. We demonstrate the imaging capabilities of the multimodal setup on custom made agar phantoms and present first measurements on ex vivo mouse and in vivo human skin samples. We compare the results with the corresponding histological images.
KW - multimodal optical setup
KW - optical coherence tomography
KW - photoacoustic tomography
KW - Raman spectroscopy
KW - ultrasound tomography
UR - http://www.scopus.com/inward/record.url?scp=85159726299&partnerID=8YFLogxK
U2 - 10.1117/12.2648257
DO - 10.1117/12.2648257
M3 - Conference contribution
AN - SCOPUS:85159726299
T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE
BT - Multimodal Biomedical Imaging XVIII
A2 - Azar, Fred S.
A2 - Intes, Xavier
A2 - Fang, Qianqian
PB - SPIE
T2 - Multimodal Biomedical Imaging XVIII 2023
Y2 - 28 January 2023 through 3 February 2023
ER -