Details
| Original language | English |
|---|---|
| Title of host publication | Biomedical Fiber Optic Instrumentation |
| Pages | 555-562 |
| Number of pages | 8 |
| Publication status | Published - 28 Jul 1994 |
| Externally published | Yes |
| Event | OE/LASE '94 - Los Angeles, CA, United States Duration: 23 Jan 1994 → 29 Jan 1994 |
Publication series
| Name | Proceedings of SPIE - The International Society for Optical Engineering |
|---|---|
| Publisher | SPIE |
| Volume | 2131 |
| ISSN (Print) | 0277-786X |
Abstract
In clinical chemistry, sensors are needed that can detect small analyte concentrations in complex physiological media. During hemodialysis it is especially important to determine the urea concentration on line in order to monitor the completion of the purification. Since no substrate flow is required in the sensor head, this technology is especially suited for monitoring in physiological solutions (no electrical contact to the patient is necessary). Biosensors were developed on the basis of optical pH sensors. This was accomplished by iminobilising enzymes directly on the sensor head. The pH shift, caused by the enzymatic reaction, is detected by the pH sensor. A multichannel fluorimeter was developed in order to monitor various analytes simultaneously, and possible pH changes in the medium. A urea biosensor was characterised and applied for urea detection during a simulated dialysis.
ASJC Scopus subject areas
- Materials Science(all)
- Electronic, Optical and Magnetic Materials
- Physics and Astronomy(all)
- Condensed Matter Physics
- Computer Science(all)
- Computer Science Applications
- Mathematics(all)
- Applied Mathematics
- Engineering(all)
- Electrical and Electronic Engineering
Cite this
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Biomedical Fiber Optic Instrumentation. 1994. p. 555-562 (Proceedings of SPIE - The International Society for Optical Engineering; Vol. 2131).
Research output: Chapter in book/report/conference proceeding › Conference contribution › Research › peer review
}
TY - GEN
T1 - Multicomponent fiberoptical biosensor for use in hemodialysis monitoring
AU - Muller, Cord
AU - Schubert, Florian
AU - Scheper, Thomas
PY - 1994/7/28
Y1 - 1994/7/28
N2 - In clinical chemistry, sensors are needed that can detect small analyte concentrations in complex physiological media. During hemodialysis it is especially important to determine the urea concentration on line in order to monitor the completion of the purification. Since no substrate flow is required in the sensor head, this technology is especially suited for monitoring in physiological solutions (no electrical contact to the patient is necessary). Biosensors were developed on the basis of optical pH sensors. This was accomplished by iminobilising enzymes directly on the sensor head. The pH shift, caused by the enzymatic reaction, is detected by the pH sensor. A multichannel fluorimeter was developed in order to monitor various analytes simultaneously, and possible pH changes in the medium. A urea biosensor was characterised and applied for urea detection during a simulated dialysis.
AB - In clinical chemistry, sensors are needed that can detect small analyte concentrations in complex physiological media. During hemodialysis it is especially important to determine the urea concentration on line in order to monitor the completion of the purification. Since no substrate flow is required in the sensor head, this technology is especially suited for monitoring in physiological solutions (no electrical contact to the patient is necessary). Biosensors were developed on the basis of optical pH sensors. This was accomplished by iminobilising enzymes directly on the sensor head. The pH shift, caused by the enzymatic reaction, is detected by the pH sensor. A multichannel fluorimeter was developed in order to monitor various analytes simultaneously, and possible pH changes in the medium. A urea biosensor was characterised and applied for urea detection during a simulated dialysis.
UR - http://www.scopus.com/inward/record.url?scp=85033106478&partnerID=8YFLogxK
U2 - 10.1117/12.180755
DO - 10.1117/12.180755
M3 - Conference contribution
AN - SCOPUS:85033106478
T3 - Proceedings of SPIE - The International Society for Optical Engineering
SP - 555
EP - 562
BT - Biomedical Fiber Optic Instrumentation
T2 - OE/LASE '94
Y2 - 23 January 1994 through 29 January 1994
ER -