Mueller Matrix Measurement of Electrospun Fiber Scaffolds for Tissue Engineering

Research output: Contribution to journalArticleResearchpeer review

Authors

  • Dierk Fricke
  • Alexander Becker
  • Lennart Jütte
  • Michael Bode
  • Dominik de Cassan
  • Merve Wollweber
  • Birgit Glasmacher
  • Bernhard Roth

External Research Organisations

  • Technische Universität Braunschweig
  • Laser Zentrum Hannover e.V. (LZH)
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Details

Original languageEnglish
Article number2062
JournalPolymers
Volume11
Issue number12
Early online date11 Dec 2019
Publication statusPublished - Dec 2019

Abstract

Electrospun fiber scaffolds are gaining in importance in the area of tissue engineering. They can be used, for example, to fabricate graded implants to mimic the tendon bone junction. For the grading of the tensile strength of the fiber scaffolds, the orientation of the fibers plays a major role. This is currently measured by hand in scanning electron microscope (SEM) images. In this work, a correlation between polarimetric information generated by measuring the Mueller matrix (MM) and the orientation of the fibers of electrospun fiber scaffolds is reported. For this, the MM of fiber scaffolds, which were manufactured with different production parameters, was measured and analyzed. These data were correlated with fiber orientation and mechanical properties, which were evaluated in an established manner. We found that by measurement of the MM the production parameters as well as the relative orientation of the fibers in space can be determined. Thus, the MM measurement is suitable as an alternative tool for non-contact, non-destructive determination of the production parameters and, thus, the degree of alignment of electrospun fiber scaffolds.

Keywords

    Electrospinning, Fiber alignment, Mueller matrix, Polycaprolactone, Tissue engineering

ASJC Scopus subject areas

Cite this

Mueller Matrix Measurement of Electrospun Fiber Scaffolds for Tissue Engineering. / Fricke, Dierk; Becker, Alexander; Jütte, Lennart et al.
In: Polymers, Vol. 11, No. 12, 2062, 12.2019.

Research output: Contribution to journalArticleResearchpeer review

Fricke, D, Becker, A, Jütte, L, Bode, M, de Cassan, D, Wollweber, M, Glasmacher, B & Roth, B 2019, 'Mueller Matrix Measurement of Electrospun Fiber Scaffolds for Tissue Engineering', Polymers, vol. 11, no. 12, 2062. https://doi.org/10.3390/polym11122062, https://doi.org/10.15488/10768
Fricke, D., Becker, A., Jütte, L., Bode, M., de Cassan, D., Wollweber, M., Glasmacher, B., & Roth, B. (2019). Mueller Matrix Measurement of Electrospun Fiber Scaffolds for Tissue Engineering. Polymers, 11(12), Article 2062. https://doi.org/10.3390/polym11122062, https://doi.org/10.15488/10768
Fricke D, Becker A, Jütte L, Bode M, de Cassan D, Wollweber M et al. Mueller Matrix Measurement of Electrospun Fiber Scaffolds for Tissue Engineering. Polymers. 2019 Dec;11(12):2062. Epub 2019 Dec 11. doi: 10.3390/polym11122062, 10.15488/10768
Fricke, Dierk ; Becker, Alexander ; Jütte, Lennart et al. / Mueller Matrix Measurement of Electrospun Fiber Scaffolds for Tissue Engineering. In: Polymers. 2019 ; Vol. 11, No. 12.
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abstract = "Electrospun fiber scaffolds are gaining in importance in the area of tissue engineering. They can be used, for example, to fabricate graded implants to mimic the tendon bone junction. For the grading of the tensile strength of the fiber scaffolds, the orientation of the fibers plays a major role. This is currently measured by hand in scanning electron microscope (SEM) images. In this work, a correlation between polarimetric information generated by measuring the Mueller matrix (MM) and the orientation of the fibers of electrospun fiber scaffolds is reported. For this, the MM of fiber scaffolds, which were manufactured with different production parameters, was measured and analyzed. These data were correlated with fiber orientation and mechanical properties, which were evaluated in an established manner. We found that by measurement of the MM the production parameters as well as the relative orientation of the fibers in space can be determined. Thus, the MM measurement is suitable as an alternative tool for non-contact, non-destructive determination of the production parameters and, thus, the degree of alignment of electrospun fiber scaffolds.",
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