Details
| Original language | English |
|---|---|
| Article number | #274423 |
| Pages (from-to) | 177-192 |
| Number of pages | 16 |
| Journal | Biomedical Optics Express |
| Volume | 8 |
| Issue number | 1 |
| Publication status | Published - 8 Dec 2016 |
Abstract
Can photothermal gold nanoparticle mediated laser manipulation be applied to induce cardiac contraction? Based on our previous work, we present a novel concept of cell stimulation. A 532 nm picosecond laser was employed to heat gold nanoparticles on cardiomyocytes. This leads to calcium oscillations in the HL-1 cardiomyocyte cell line. As calcium is connected to the contractility, we aimed to alter the contraction rate of native and stem cell derived cardiomyocytes. A contraction rate increase was particularly observed in calcium containing buffer with neonatal rat cardiomyocytes. Consequently, the study provides conceptual ideas for a light based, nanoparticle mediated stimulation system.
Keywords
- Biology and medicine, Optical tweezers or optical manipulation, Photothermal effects
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Biotechnology
- Physics and Astronomy(all)
- Atomic and Molecular Physics, and Optics
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In: Biomedical Optics Express, Vol. 8, No. 1, #274423, 08.12.2016, p. 177-192.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Modulation of cardiomyocyte activity using pulsed laser irradiated gold nanoparticles
AU - Gentemann, Lara
AU - Kalies, Stefan
AU - Coffee, Michelle
AU - Meyer, Heiko
AU - Ripken, Tammo
AU - Heisterkamp, Alexander
AU - Zweigerdt, Robert
AU - Heinemann, Dag
PY - 2016/12/8
Y1 - 2016/12/8
N2 - Can photothermal gold nanoparticle mediated laser manipulation be applied to induce cardiac contraction? Based on our previous work, we present a novel concept of cell stimulation. A 532 nm picosecond laser was employed to heat gold nanoparticles on cardiomyocytes. This leads to calcium oscillations in the HL-1 cardiomyocyte cell line. As calcium is connected to the contractility, we aimed to alter the contraction rate of native and stem cell derived cardiomyocytes. A contraction rate increase was particularly observed in calcium containing buffer with neonatal rat cardiomyocytes. Consequently, the study provides conceptual ideas for a light based, nanoparticle mediated stimulation system.
AB - Can photothermal gold nanoparticle mediated laser manipulation be applied to induce cardiac contraction? Based on our previous work, we present a novel concept of cell stimulation. A 532 nm picosecond laser was employed to heat gold nanoparticles on cardiomyocytes. This leads to calcium oscillations in the HL-1 cardiomyocyte cell line. As calcium is connected to the contractility, we aimed to alter the contraction rate of native and stem cell derived cardiomyocytes. A contraction rate increase was particularly observed in calcium containing buffer with neonatal rat cardiomyocytes. Consequently, the study provides conceptual ideas for a light based, nanoparticle mediated stimulation system.
KW - Biology and medicine
KW - Optical tweezers or optical manipulation
KW - Photothermal effects
UR - http://www.scopus.com/inward/record.url?scp=85008873310&partnerID=8YFLogxK
U2 - 10.1364/BOE.8.000177
DO - 10.1364/BOE.8.000177
M3 - Article
AN - SCOPUS:85008873310
VL - 8
SP - 177
EP - 192
JO - Biomedical Optics Express
JF - Biomedical Optics Express
SN - 2156-7085
IS - 1
M1 - #274423
ER -