Details
| Original language | English |
|---|---|
| Pages (from-to) | 13888–13896 |
| Journal | Analytical chemistry |
| Volume | 96 |
| Issue number | 34 |
| Early online date | 17 Aug 2024 |
| Publication status | Published - 27 Aug 2024 |
Abstract
ASJC Scopus subject areas
- Chemistry(all)
- Analytical Chemistry
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In: Analytical chemistry, Vol. 96, No. 34, 27.08.2024, p. 13888–13896.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Modular Chip-Based nanoSFC-MS for Ultrafast Separations
AU - Weise, C.
AU - Schirmer, M.
AU - Polack, M.
AU - Korell, A.
AU - Westphal, H.
AU - Schwieger, J.
AU - Warias, R.
AU - Zimmermann, S.
AU - Belder, D.
N1 - Publisher Copyright: © 2024 The Authors. Published by American Chemical Society.
PY - 2024/8/27
Y1 - 2024/8/27
N2 - This study presents the development of a miniaturized device for supercritical fluid chromatography coupled with mass spectrometry. The chip-based, modular nanoSFC approach utilizes a particle-packed nanobore column embedded between two monolithically structured glass chips. A microtee in the pre-column section ensures picoliter sample loads onto the column, while a microcross chip structure fluidically controls the column backpressure. The restrictive emitter and the minimal post-column volume of 16 nL prevent mobile phase decompression and analyte dilution, maintaining chromatographic integrity during transfer to the atmospheric pressure MS interface. This facilitates high-speed chiral separations in less than 80 s with high reproducibility.
AB - This study presents the development of a miniaturized device for supercritical fluid chromatography coupled with mass spectrometry. The chip-based, modular nanoSFC approach utilizes a particle-packed nanobore column embedded between two monolithically structured glass chips. A microtee in the pre-column section ensures picoliter sample loads onto the column, while a microcross chip structure fluidically controls the column backpressure. The restrictive emitter and the minimal post-column volume of 16 nL prevent mobile phase decompression and analyte dilution, maintaining chromatographic integrity during transfer to the atmospheric pressure MS interface. This facilitates high-speed chiral separations in less than 80 s with high reproducibility.
UR - http://www.scopus.com/inward/record.url?scp=85201584918&partnerID=8YFLogxK
U2 - 10.1021/acs.analchem.4c01958
DO - 10.1021/acs.analchem.4c01958
M3 - Article
VL - 96
SP - 13888
EP - 13896
JO - Analytical chemistry
JF - Analytical chemistry
SN - 0003-2700
IS - 34
ER -