Details
| Original language | English |
|---|---|
| Pages (from-to) | S39-S41 |
| Journal | Biomedizinische Technik |
| Volume | 59 |
| Publication status | Published - 1 Oct 2014 |
Abstract
The development of hemocompatible biomaterials and vascular implants is one of the biggest tasks in biomedical engineering. Due to the fact that there are no standardized test setups a modified CHANDLER LOOP system was designed for the in vitro testing of biomaterials and cardiovascular implants. The modified system consists of disks, which serve as carriers for tubes or vascular implants. They are placed in a rig and are secured by locking pins, which are attached to the locking device. The rig is mounted in a water bath and rotated by an electric motor. By this technique up to 20 samples can be tested simultaneously. The modular design leads to an improvement in handling compared to other similar systems. The disk concept ensures perfect circularity of the tubes and undisturbed flow conditions during testing. The system includes built-in sensors capaple of controlling and recording roatating velocity and temprature throughout test series. A study was designed to validate the new in vitro system by comparing the results to an established system at the institute1. Therefore medical tubes are partly filled with anticoagulated blood and rotated for 60 minutes in each system. The study focused on an improvement of handling and background activation. The mounting duration decreased up to 56% compared to the established system. The decrease of thrombocytes was similar with about 12% in both systems. The highest rate of hemolysis was 0,21% for the modfied and 0,1% for the established system. The fast removal of disks enables time dependent test series with short standing times. The low background activation and improved handling in combination with the measurement technique increases the reproducibility of test series and qualifies the modified CHANDLER LOOP System for the testing of cardiovascular implants and materials.
ASJC Scopus subject areas
- Engineering(all)
- Biomedical Engineering
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In: Biomedizinische Technik, Vol. 59, 01.10.2014, p. S39-S41.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Modified Chandler Loop system for dynamic hemocompatibility testing of vascular implants
AU - Jordan, M.
AU - Mueller, M.
AU - Kortlepel, R.
AU - Glasmacher, B.
PY - 2014/10/1
Y1 - 2014/10/1
N2 - The development of hemocompatible biomaterials and vascular implants is one of the biggest tasks in biomedical engineering. Due to the fact that there are no standardized test setups a modified CHANDLER LOOP system was designed for the in vitro testing of biomaterials and cardiovascular implants. The modified system consists of disks, which serve as carriers for tubes or vascular implants. They are placed in a rig and are secured by locking pins, which are attached to the locking device. The rig is mounted in a water bath and rotated by an electric motor. By this technique up to 20 samples can be tested simultaneously. The modular design leads to an improvement in handling compared to other similar systems. The disk concept ensures perfect circularity of the tubes and undisturbed flow conditions during testing. The system includes built-in sensors capaple of controlling and recording roatating velocity and temprature throughout test series. A study was designed to validate the new in vitro system by comparing the results to an established system at the institute1. Therefore medical tubes are partly filled with anticoagulated blood and rotated for 60 minutes in each system. The study focused on an improvement of handling and background activation. The mounting duration decreased up to 56% compared to the established system. The decrease of thrombocytes was similar with about 12% in both systems. The highest rate of hemolysis was 0,21% for the modfied and 0,1% for the established system. The fast removal of disks enables time dependent test series with short standing times. The low background activation and improved handling in combination with the measurement technique increases the reproducibility of test series and qualifies the modified CHANDLER LOOP System for the testing of cardiovascular implants and materials.
AB - The development of hemocompatible biomaterials and vascular implants is one of the biggest tasks in biomedical engineering. Due to the fact that there are no standardized test setups a modified CHANDLER LOOP system was designed for the in vitro testing of biomaterials and cardiovascular implants. The modified system consists of disks, which serve as carriers for tubes or vascular implants. They are placed in a rig and are secured by locking pins, which are attached to the locking device. The rig is mounted in a water bath and rotated by an electric motor. By this technique up to 20 samples can be tested simultaneously. The modular design leads to an improvement in handling compared to other similar systems. The disk concept ensures perfect circularity of the tubes and undisturbed flow conditions during testing. The system includes built-in sensors capaple of controlling and recording roatating velocity and temprature throughout test series. A study was designed to validate the new in vitro system by comparing the results to an established system at the institute1. Therefore medical tubes are partly filled with anticoagulated blood and rotated for 60 minutes in each system. The study focused on an improvement of handling and background activation. The mounting duration decreased up to 56% compared to the established system. The decrease of thrombocytes was similar with about 12% in both systems. The highest rate of hemolysis was 0,21% for the modfied and 0,1% for the established system. The fast removal of disks enables time dependent test series with short standing times. The low background activation and improved handling in combination with the measurement technique increases the reproducibility of test series and qualifies the modified CHANDLER LOOP System for the testing of cardiovascular implants and materials.
UR - http://www.scopus.com/inward/record.url?scp=84908157446&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:84908157446
VL - 59
SP - S39-S41
JO - Biomedizinische Technik
JF - Biomedizinische Technik
SN - 0013-5585
ER -