Details
| Original language | English |
|---|---|
| Pages (from-to) | 323-329 |
| Number of pages | 7 |
| Journal | Bioprocess Engineering |
| Volume | 16 |
| Issue number | 6 |
| Publication status | Published - May 1997 |
Abstract
Two novel approaches for modelling processes that can be described by a sequence of phases (metabolic states) are suggested and applied to Escherichia Coli fermentations. The first approach uses a multi-compartment model framework, coupled with knowledge-based logic. In X the second approach the multi-compartment model is reduced into the Variable Structure Model consisting of a battery of alternative submodels, each of which qualitatively represents one of the process steps. Furthermore, simulated intracellular process variables are compared with the output of a multi-wavelength fluorosensor and excitation-emission pairs that predict best these variables are identified.
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Biotechnology
- Immunology and Microbiology(all)
- Applied Microbiology and Biotechnology
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In: Bioprocess Engineering, Vol. 16, No. 6, 05.1997, p. 323-329.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Modelling of E. Coli fermentations: comparison of multicompartment and variable structure models
AU - Tartakovsky, B.
AU - Sheintuch, M.
AU - Hilmer, J. M.
AU - Scheper, T.
N1 - Funding information: BT was supported by the Minerva foundation. The experimental work was supported by the EEC (BRIT-EUram BRE2-CT-1005, BE 7991). Authors are thankful to B. Dainson (Department of Chemical Engineering, Technion) for useful discussions.
PY - 1997/5
Y1 - 1997/5
N2 - Two novel approaches for modelling processes that can be described by a sequence of phases (metabolic states) are suggested and applied to Escherichia Coli fermentations. The first approach uses a multi-compartment model framework, coupled with knowledge-based logic. In X the second approach the multi-compartment model is reduced into the Variable Structure Model consisting of a battery of alternative submodels, each of which qualitatively represents one of the process steps. Furthermore, simulated intracellular process variables are compared with the output of a multi-wavelength fluorosensor and excitation-emission pairs that predict best these variables are identified.
AB - Two novel approaches for modelling processes that can be described by a sequence of phases (metabolic states) are suggested and applied to Escherichia Coli fermentations. The first approach uses a multi-compartment model framework, coupled with knowledge-based logic. In X the second approach the multi-compartment model is reduced into the Variable Structure Model consisting of a battery of alternative submodels, each of which qualitatively represents one of the process steps. Furthermore, simulated intracellular process variables are compared with the output of a multi-wavelength fluorosensor and excitation-emission pairs that predict best these variables are identified.
UR - http://www.scopus.com/inward/record.url?scp=85047677192&partnerID=8YFLogxK
U2 - 10.1007/PL00008947
DO - 10.1007/PL00008947
M3 - Article
AN - SCOPUS:85047677192
VL - 16
SP - 323
EP - 329
JO - Bioprocess Engineering
JF - Bioprocess Engineering
SN - 0178-515X
IS - 6
ER -