Details
| Translated title of the contribution | Modelling, Simulation, and control of a gas membrane cellular culture reactor |
|---|---|
| Original language | German |
| Pages (from-to) | 66-74 |
| Number of pages | 9 |
| Journal | At-Automatisierungstechnik |
| Volume | 37 |
| Issue number | 1-12 |
| Publication status | Published - Dec 1989 |
| Externally published | Yes |
Abstract
The cultivation of human, animal, and vegetahle cell lines in submersed methods comprises many biotechnical problems, which are not found in the cultivation of bacteria or yeasts. Especially high shear loads and foaming must be prevented in the bioreactor. In this contribution the design of an unconventional control scheme for two process-determining parameters in cellular culture technology is presented, namely the partial pressure pO2of dissolved oxygen and the concentration of free Hydrogen ions (ph value). Both variables are simultaneously controlled by adjusting a suitable gas mixture in a new type of reactor, which is fed with gas through a Hydrophobie membran without bubbles. In the first part of this contribution modelling and Simulation of the biological and engineering process, which strictly speaking must be viewed as a distributed parameter system, is presented. The secondpart then shows the theoretical analysis Simulation and realization of the chosen control scheme. It was implemented in the industrially used multi-channel Controller MICON P-200 (VDO Measurement and Control Engineering. Hannover). Both contributions are verified by experimental data.
ASJC Scopus subject areas
- Engineering(all)
- Control and Systems Engineering
- Computer Science(all)
- Computer Science Applications
- Engineering(all)
- Electrical and Electronic Engineering
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In: At-Automatisierungstechnik, Vol. 37, No. 1-12, 12.1989, p. 66-74.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Modellbildung, Simulation und Regelung eines membranbegasten Zellkulturreaktors
AU - Luttmann, R.
AU - Bellgardt, K. H.
AU - Nothnagel, J.
AU - Piehl, P.
AU - Lehmann, J.
PY - 1989/12
Y1 - 1989/12
N2 - The cultivation of human, animal, and vegetahle cell lines in submersed methods comprises many biotechnical problems, which are not found in the cultivation of bacteria or yeasts. Especially high shear loads and foaming must be prevented in the bioreactor. In this contribution the design of an unconventional control scheme for two process-determining parameters in cellular culture technology is presented, namely the partial pressure pO2of dissolved oxygen and the concentration of free Hydrogen ions (ph value). Both variables are simultaneously controlled by adjusting a suitable gas mixture in a new type of reactor, which is fed with gas through a Hydrophobie membran without bubbles. In the first part of this contribution modelling and Simulation of the biological and engineering process, which strictly speaking must be viewed as a distributed parameter system, is presented. The secondpart then shows the theoretical analysis Simulation and realization of the chosen control scheme. It was implemented in the industrially used multi-channel Controller MICON P-200 (VDO Measurement and Control Engineering. Hannover). Both contributions are verified by experimental data.
AB - The cultivation of human, animal, and vegetahle cell lines in submersed methods comprises many biotechnical problems, which are not found in the cultivation of bacteria or yeasts. Especially high shear loads and foaming must be prevented in the bioreactor. In this contribution the design of an unconventional control scheme for two process-determining parameters in cellular culture technology is presented, namely the partial pressure pO2of dissolved oxygen and the concentration of free Hydrogen ions (ph value). Both variables are simultaneously controlled by adjusting a suitable gas mixture in a new type of reactor, which is fed with gas through a Hydrophobie membran without bubbles. In the first part of this contribution modelling and Simulation of the biological and engineering process, which strictly speaking must be viewed as a distributed parameter system, is presented. The secondpart then shows the theoretical analysis Simulation and realization of the chosen control scheme. It was implemented in the industrially used multi-channel Controller MICON P-200 (VDO Measurement and Control Engineering. Hannover). Both contributions are verified by experimental data.
UR - http://www.scopus.com/inward/record.url?scp=0342993270&partnerID=8YFLogxK
U2 - 10.1524/auto.1989.37.112.66
DO - 10.1524/auto.1989.37.112.66
M3 - Artikel
AN - SCOPUS:0342993270
VL - 37
SP - 66
EP - 74
JO - At-Automatisierungstechnik
JF - At-Automatisierungstechnik
SN - 0178-2312
IS - 1-12
ER -