Details
| Original language | English |
|---|---|
| Pages (from-to) | 625-631 |
| Number of pages | 7 |
| Journal | Nature chemical biology |
| Volume | 11 |
| Issue number | 9 |
| Publication status | Published - 18 Aug 2015 |
Abstract
A wide variety of enzymatic pathways that produce specialized metabolites in bacteria, fungi and plants are known to be encoded in biosynthetic gene clusters. Information about these clusters, pathways and metabolites is currently dispersed throughout the literature, making it difficult to exploit. To facilitate consistent and systematic deposition and retrieval of data on biosynthetic gene clusters, we propose the Minimum Information about a Biosynthetic Gene cluster (MIBiG) data standard.
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Molecular Biology
- Biochemistry, Genetics and Molecular Biology(all)
- Cell Biology
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In: Nature chemical biology, Vol. 11, No. 9, 18.08.2015, p. 625-631.
Research output: Contribution to journal › Review article › Research › peer review
}
TY - JOUR
T1 - Minimum Information about a Biosynthetic Gene cluster
AU - Medema, Marnix H.
AU - Kottmann, Renzo
AU - Yilmaz, Pelin
AU - Cummings, Matthew
AU - Biggins, John B.
AU - Blin, Kai
AU - De Bruijn, Irene
AU - Chooi, Yit Heng
AU - Claesen, Jan
AU - Coates, R. Cameron
AU - Cruz-Morales, Pablo
AU - Duddela, Srikanth
AU - Düsterhus, Stephanie
AU - Edwards, Daniel J.
AU - Fewer, David P.
AU - Garg, Neha
AU - Geiger, Christoph
AU - Gomez-Escribano, Juan Pablo
AU - Greule, Anja
AU - Hadjithomas, Michalis
AU - Haines, Anthony S.
AU - Helfrich, Eric J.N.
AU - Hillwig, Matthew L.
AU - Ishida, Keishi
AU - Jones, Adam C.
AU - Jones, Carla S.
AU - Jungmann, Katrin
AU - Kegler, Carsten
AU - Kim, Hyun Uk
AU - Kötter, Peter
AU - Krug, Daniel
AU - Masschelein, Joleen
AU - Melnik, Alexey V.
AU - Mantovani, Simone M.
AU - Monroe, Emily A.
AU - Moore, Marcus
AU - Moss, Nathan
AU - Nützmann, Hans Wilhelm
AU - Pan, Guohui
AU - Pati, Amrita
AU - Petras, Daniel
AU - Reen, F. Jerry
AU - Rosconi, Federico
AU - Rui, Zhe
AU - Tian, Zhenhua
AU - Tobias, Nicholas J.
AU - Tsunematsu, Yuta
AU - Wiemann, Philipp
AU - Wyckoff, Elizabeth
AU - Cox, Russell J.
N1 - Funding information: M.H.M. was supported by a Rubicon fellowship of the Netherlands Organization for Scientific Research (NWO; Rubicon 825.13.001). The work of R.K. was supported by the European Union’s Seventh Framework Programme (Joint Call OCEAN.2011–2: Marine microbial diversity— new insights into marine ecosystems functioning and its biotechnological potential) under the grant agreement no. 287589 (Micro B3). M.C. was supported by a Biotechnology and Biological Sciences Research Council (BBSRC) studentship (BB/J014478/1). The GSC is supported by funding from the Natural Environment Research Council (UK), the National Institute for Energy Ethics and Society (NIEeS; UK), the Gordon and Betty Moore Foundation, the National Science Foundation (NSF; US) and the US Department of Energy. The Manchester Synthetic Biology Research Centre, SYNBIOCHEM, is supported by BBSRC/ Engineering and Physical Sciences Research Council (EPSRC) grant BB/M017702/1. We thank P. d’Agostino, P.R. August, R. Chau, C.D. Deane, S. Diethelm, L. Fernandez-Martinez, A. El Gamal, C. Garcia De Gonzalo, T.H. Grossman, C.-J. Huang, S. Kodani, A.L. Leandrini, I.A. MacNeil, M. Metelev, E.M. Molly, C. Olano, M. Ortega, L. Ray, K. Reynolds, A. Ross, I.N. Silva, R. Teufel, G. Thibodeaux, J. Tietz and D. Widdick for their contributions in the community annotation. We thank R. Baltz, M. Bibb, C. Boddy, C. Corre, E. Dittmann, H. Gramajo, N. Ichikawa, H. Ikeda, P. Jensen, C. Khosla, R. Li, M. Marahiel, D. Mohanty, C. Moore, W. Nierman, D.-C. Oh, E. Schmidt, Y. Shen, D. Stevens, B. Tudzynski and S. Van Lanen for useful comments on an early draft version of the community standard. We are grateful to three anonymous referees for their constructive suggestions.
PY - 2015/8/18
Y1 - 2015/8/18
N2 - A wide variety of enzymatic pathways that produce specialized metabolites in bacteria, fungi and plants are known to be encoded in biosynthetic gene clusters. Information about these clusters, pathways and metabolites is currently dispersed throughout the literature, making it difficult to exploit. To facilitate consistent and systematic deposition and retrieval of data on biosynthetic gene clusters, we propose the Minimum Information about a Biosynthetic Gene cluster (MIBiG) data standard.
AB - A wide variety of enzymatic pathways that produce specialized metabolites in bacteria, fungi and plants are known to be encoded in biosynthetic gene clusters. Information about these clusters, pathways and metabolites is currently dispersed throughout the literature, making it difficult to exploit. To facilitate consistent and systematic deposition and retrieval of data on biosynthetic gene clusters, we propose the Minimum Information about a Biosynthetic Gene cluster (MIBiG) data standard.
UR - http://www.scopus.com/inward/record.url?scp=84939557642&partnerID=8YFLogxK
U2 - 10.1038/nchembio.1890
DO - 10.1038/nchembio.1890
M3 - Review article
C2 - 26284661
AN - SCOPUS:84939557642
VL - 11
SP - 625
EP - 631
JO - Nature chemical biology
JF - Nature chemical biology
SN - 1552-4450
IS - 9
ER -