Details
| Original language | English |
|---|---|
| Pages (from-to) | 777-786 |
| Number of pages | 10 |
| Journal | Analytical chemistry |
| Volume | 94 |
| Issue number | 2 |
| Early online date | 5 Jan 2022 |
| Publication status | Published - 18 Jan 2022 |
Abstract
Ion mobility spectrometers (IMS) are well suited for detecting trace gases down to levels at ppb v and even ppt v within 1 s of analysis time when using chemical ionization. The measuring principle is based on the separation and detection of the ionized constituents of a sample. Depending on the sample composition, certain ionization sources create both positive and negative analyte ions, but the simultaneous detection of both ion polarities usually requires two drift tubes. Contained within this effort, we present an alternative approach for detecting both ion polarities using one single drift tube that can switch the polarity of the drift tube within 12 ms. This technique allows for generating one positive and one negative ion mobility spectrum, each with a drift time range of 13 ms (minimum reduced ion mobility of K 0 = 0.72 cm 2 V –1 s –1), within a total experiment time of 50 ms. Additionally, ions are continuously generated in the ionization region during both the polarity switching and the analysis of one of the polarities, which allows for an effective ionization/reaction time of 25 ms. Comparable to the performance of similar instrument designs we reported previously, the presented device has a high resolving power of R P = 70 with a drift length of 51 mm. The limits of detection are for the monomers between 70 and 370 ppt v and for the dimers between 450 and 800 ppt v for 1 s of averaging for various ketones, methyl salicylate, and chlorinated hydrocarbons. Although this work focuses on applying ultra-fast polarity switching to an existing IMS, the techniques shown here may be applied to other IMS implementations for different applications.
ASJC Scopus subject areas
- Chemistry(all)
- Analytical Chemistry
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In: Analytical chemistry, Vol. 94, No. 2, 18.01.2022, p. 777-786.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Miniaturized Drift Tube Ion Mobility Spectrometer with Ultra-Fast Polarity Switching
AU - Hitzemann, Moritz
AU - Kirk, Ansgar T.
AU - Lippmann, Martin
AU - Bohnhorst, Alexander
AU - Zimmermann, Stefan
N1 - Funding Information: This work was supported by the German Federal Ministry of Education and Research (BMBF) under the Grant 13N15238. The authors acknowledge Cameron Naylor for his advice during editing.
PY - 2022/1/18
Y1 - 2022/1/18
N2 - Ion mobility spectrometers (IMS) are well suited for detecting trace gases down to levels at ppb v and even ppt v within 1 s of analysis time when using chemical ionization. The measuring principle is based on the separation and detection of the ionized constituents of a sample. Depending on the sample composition, certain ionization sources create both positive and negative analyte ions, but the simultaneous detection of both ion polarities usually requires two drift tubes. Contained within this effort, we present an alternative approach for detecting both ion polarities using one single drift tube that can switch the polarity of the drift tube within 12 ms. This technique allows for generating one positive and one negative ion mobility spectrum, each with a drift time range of 13 ms (minimum reduced ion mobility of K 0 = 0.72 cm 2 V –1 s –1), within a total experiment time of 50 ms. Additionally, ions are continuously generated in the ionization region during both the polarity switching and the analysis of one of the polarities, which allows for an effective ionization/reaction time of 25 ms. Comparable to the performance of similar instrument designs we reported previously, the presented device has a high resolving power of R P = 70 with a drift length of 51 mm. The limits of detection are for the monomers between 70 and 370 ppt v and for the dimers between 450 and 800 ppt v for 1 s of averaging for various ketones, methyl salicylate, and chlorinated hydrocarbons. Although this work focuses on applying ultra-fast polarity switching to an existing IMS, the techniques shown here may be applied to other IMS implementations for different applications.
AB - Ion mobility spectrometers (IMS) are well suited for detecting trace gases down to levels at ppb v and even ppt v within 1 s of analysis time when using chemical ionization. The measuring principle is based on the separation and detection of the ionized constituents of a sample. Depending on the sample composition, certain ionization sources create both positive and negative analyte ions, but the simultaneous detection of both ion polarities usually requires two drift tubes. Contained within this effort, we present an alternative approach for detecting both ion polarities using one single drift tube that can switch the polarity of the drift tube within 12 ms. This technique allows for generating one positive and one negative ion mobility spectrum, each with a drift time range of 13 ms (minimum reduced ion mobility of K 0 = 0.72 cm 2 V –1 s –1), within a total experiment time of 50 ms. Additionally, ions are continuously generated in the ionization region during both the polarity switching and the analysis of one of the polarities, which allows for an effective ionization/reaction time of 25 ms. Comparable to the performance of similar instrument designs we reported previously, the presented device has a high resolving power of R P = 70 with a drift length of 51 mm. The limits of detection are for the monomers between 70 and 370 ppt v and for the dimers between 450 and 800 ppt v for 1 s of averaging for various ketones, methyl salicylate, and chlorinated hydrocarbons. Although this work focuses on applying ultra-fast polarity switching to an existing IMS, the techniques shown here may be applied to other IMS implementations for different applications.
UR - http://www.scopus.com/inward/record.url?scp=85122679886&partnerID=8YFLogxK
U2 - 10.1021/acs.analchem.1c03268
DO - 10.1021/acs.analchem.1c03268
M3 - Article
VL - 94
SP - 777
EP - 786
JO - Analytical chemistry
JF - Analytical chemistry
SN - 0003-2700
IS - 2
ER -