Details
| Original language | English |
|---|---|
| Article number | 124009 |
| Journal | Journal of Optics |
| Volume | 12 |
| Issue number | 12 |
| Publication status | Published - 11 Nov 2010 |
| Externally published | Yes |
Abstract
The fabrication of defined surface topographies and three-dimensional structures is a challenging process for various applications, e.g. in photonics and biomedicine. Laser-based technologies provide a promising approach for the production of such structures. The advantages of femtosecond laser ablation and two-photon polymerization for microstructuring are well known. However, these methods cannot be applied to all materials and are limited by their high cost and long production time. In this study, biomedical applications of an indirect rapid prototyping, molding microreplication of laser-fabricated two- and three-dimensional structures are examined. We demonstrate that by this method any laser-generated surface topography as well as three-dimensional structures can be replicated in various materials without losing the original geometry. The replication into multiple copies enables fast and perfect reproducibility of original microstructures for investigations of cell-surface interactions. Compared to unstructured materials, we observe that microstructures have strong influence on morphology and localization of fibroblasts, whereas neuroblastoma cells are not negatively affected.
Keywords
- Biomedical engineering, Femtosecond lasers, Indirect rapid prototyping, Microreplication, Soft lithography, Two-photon polymerization
ASJC Scopus subject areas
- Materials Science(all)
- Electronic, Optical and Magnetic Materials
- Physics and Astronomy(all)
- Atomic and Molecular Physics, and Optics
Cite this
- Standard
- Harvard
- Apa
- Vancouver
- BibTeX
- RIS
In: Journal of Optics, Vol. 12, No. 12, 124009, 11.11.2010.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Microreplication of laser-fabricated surface and three-dimensional structures
AU - Koroleva, Anastasia
AU - Schlie, Sabrina
AU - Fadeeva, Elena
AU - Gittard, Shaun D.
AU - Miller, Philip
AU - Ovsianikov, Aleksandr
AU - Koch, Jürgen
AU - Narayan, Roger J.
AU - Chichkov, Boris N.
PY - 2010/11/11
Y1 - 2010/11/11
N2 - The fabrication of defined surface topographies and three-dimensional structures is a challenging process for various applications, e.g. in photonics and biomedicine. Laser-based technologies provide a promising approach for the production of such structures. The advantages of femtosecond laser ablation and two-photon polymerization for microstructuring are well known. However, these methods cannot be applied to all materials and are limited by their high cost and long production time. In this study, biomedical applications of an indirect rapid prototyping, molding microreplication of laser-fabricated two- and three-dimensional structures are examined. We demonstrate that by this method any laser-generated surface topography as well as three-dimensional structures can be replicated in various materials without losing the original geometry. The replication into multiple copies enables fast and perfect reproducibility of original microstructures for investigations of cell-surface interactions. Compared to unstructured materials, we observe that microstructures have strong influence on morphology and localization of fibroblasts, whereas neuroblastoma cells are not negatively affected.
AB - The fabrication of defined surface topographies and three-dimensional structures is a challenging process for various applications, e.g. in photonics and biomedicine. Laser-based technologies provide a promising approach for the production of such structures. The advantages of femtosecond laser ablation and two-photon polymerization for microstructuring are well known. However, these methods cannot be applied to all materials and are limited by their high cost and long production time. In this study, biomedical applications of an indirect rapid prototyping, molding microreplication of laser-fabricated two- and three-dimensional structures are examined. We demonstrate that by this method any laser-generated surface topography as well as three-dimensional structures can be replicated in various materials without losing the original geometry. The replication into multiple copies enables fast and perfect reproducibility of original microstructures for investigations of cell-surface interactions. Compared to unstructured materials, we observe that microstructures have strong influence on morphology and localization of fibroblasts, whereas neuroblastoma cells are not negatively affected.
KW - Biomedical engineering
KW - Femtosecond lasers
KW - Indirect rapid prototyping
KW - Microreplication
KW - Soft lithography
KW - Two-photon polymerization
UR - http://www.scopus.com/inward/record.url?scp=78249240622&partnerID=8YFLogxK
U2 - 10.1088/2040-8978/12/12/124009
DO - 10.1088/2040-8978/12/12/124009
M3 - Article
AN - SCOPUS:78249240622
VL - 12
JO - Journal of Optics
JF - Journal of Optics
SN - 2040-8978
IS - 12
M1 - 124009
ER -