Details
| Original language | English |
|---|---|
| Pages (from-to) | 16-19 |
| Number of pages | 4 |
| Journal | British Journal of Cancer |
| Volume | 37 |
| Issue number | SUPPL.3 |
| Publication status | Published - 1978 |
Abstract
The nitro radiosensitizers, metronidazole and misonidazole, have been shown to react rapidly with the sulphydryl compounds cysteine and cysteamine in the presence of ferrous ions. Similar reactions occur in the presence of copper ions but these are much slower. The initial interactions of the drugs and of oxygen with an iron-cysteine complex are extremely rapid: in the case of oxygen reaction half lives of 27 ms have been measured. Misonidazole also reacts rapidly with glutathione in the presence of ferrous ions and is subsequently reduced: metronidazole is reduced only slowly if at all. These reactions, which have been found to be inhibited by high concentrations of zinc ions, are discussed in the light of the known radiosensitizing and chemotherapeutic efficiencies of the nitro drugs and the side effect of peripheral neuropathy sometimes observed during their clinical use.
ASJC Scopus subject areas
- Medicine(all)
- Oncology
- Biochemistry, Genetics and Molecular Biology(all)
- Cancer Research
Sustainable Development Goals
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In: British Journal of Cancer, Vol. 37, No. SUPPL.3, 1978, p. 16-19.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Metronidazole (Flagyl), misonidazole (Ro 07-0582), iron, zinc and sulphur compounds in cancer therapy
AU - Bahnemann, D.
AU - Basaga, H.
AU - Dunlop, J. R.
AU - Searle, A. J.
AU - Willson, R. L.
N1 - Copyright: Copyright 2012 Elsevier B.V., All rights reserved.
PY - 1978
Y1 - 1978
N2 - The nitro radiosensitizers, metronidazole and misonidazole, have been shown to react rapidly with the sulphydryl compounds cysteine and cysteamine in the presence of ferrous ions. Similar reactions occur in the presence of copper ions but these are much slower. The initial interactions of the drugs and of oxygen with an iron-cysteine complex are extremely rapid: in the case of oxygen reaction half lives of 27 ms have been measured. Misonidazole also reacts rapidly with glutathione in the presence of ferrous ions and is subsequently reduced: metronidazole is reduced only slowly if at all. These reactions, which have been found to be inhibited by high concentrations of zinc ions, are discussed in the light of the known radiosensitizing and chemotherapeutic efficiencies of the nitro drugs and the side effect of peripheral neuropathy sometimes observed during their clinical use.
AB - The nitro radiosensitizers, metronidazole and misonidazole, have been shown to react rapidly with the sulphydryl compounds cysteine and cysteamine in the presence of ferrous ions. Similar reactions occur in the presence of copper ions but these are much slower. The initial interactions of the drugs and of oxygen with an iron-cysteine complex are extremely rapid: in the case of oxygen reaction half lives of 27 ms have been measured. Misonidazole also reacts rapidly with glutathione in the presence of ferrous ions and is subsequently reduced: metronidazole is reduced only slowly if at all. These reactions, which have been found to be inhibited by high concentrations of zinc ions, are discussed in the light of the known radiosensitizing and chemotherapeutic efficiencies of the nitro drugs and the side effect of peripheral neuropathy sometimes observed during their clinical use.
UR - http://www.scopus.com/inward/record.url?scp=0018144209&partnerID=8YFLogxK
M3 - Article
C2 - 277218
AN - SCOPUS:0018144209
VL - 37
SP - 16
EP - 19
JO - British Journal of Cancer
JF - British Journal of Cancer
SN - 0007-0920
IS - SUPPL.3
ER -