Details
| Original language | English |
|---|---|
| Article number | 127010 |
| Journal | Computational and Mathematical Methods in Medicine |
| Volume | 2015 |
| Publication status | Published - 12 Feb 2015 |
Abstract
In lungs the number of conducting airway generations as well as bifurcation patterns varies across species and shows specific characteristics relating to illnesses or gene variations. A method to characterize the topology of the mouse airway tree using scanning laser optical tomography (SLOT) tomograms is presented in this paper. It is used to test discrimination between two types of mice based on detected differences in their conducting airway pattern. Based on segmentations of the airways in these tomograms, the main spanning tree of the volume skeleton is computed. The resulting graph structure is used to distinguish between wild type and surfactant protein (SP-D) deficient knock-out mice.
ASJC Scopus subject areas
- Mathematics(all)
- Modelling and Simulation
- Biochemistry, Genetics and Molecular Biology(all)
- Immunology and Microbiology(all)
- Mathematics(all)
- Applied Mathematics
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In: Computational and Mathematical Methods in Medicine, Vol. 2015, 127010, 12.02.2015.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Method for 3D airway topology extraction
AU - Grothausmann, Roman
AU - Kellner, Manuela
AU - Heidrich, Marko
AU - Lorbeer, Raoul Amadeus
AU - Ripken, Tammo
AU - Meyer, Heiko
AU - Kuehnel, Mark P.
AU - Ochs, Matthias
AU - Rosenhahn, Bodo
PY - 2015/2/12
Y1 - 2015/2/12
N2 - In lungs the number of conducting airway generations as well as bifurcation patterns varies across species and shows specific characteristics relating to illnesses or gene variations. A method to characterize the topology of the mouse airway tree using scanning laser optical tomography (SLOT) tomograms is presented in this paper. It is used to test discrimination between two types of mice based on detected differences in their conducting airway pattern. Based on segmentations of the airways in these tomograms, the main spanning tree of the volume skeleton is computed. The resulting graph structure is used to distinguish between wild type and surfactant protein (SP-D) deficient knock-out mice.
AB - In lungs the number of conducting airway generations as well as bifurcation patterns varies across species and shows specific characteristics relating to illnesses or gene variations. A method to characterize the topology of the mouse airway tree using scanning laser optical tomography (SLOT) tomograms is presented in this paper. It is used to test discrimination between two types of mice based on detected differences in their conducting airway pattern. Based on segmentations of the airways in these tomograms, the main spanning tree of the volume skeleton is computed. The resulting graph structure is used to distinguish between wild type and surfactant protein (SP-D) deficient knock-out mice.
UR - http://www.scopus.com/inward/record.url?scp=84924118440&partnerID=8YFLogxK
U2 - 10.1155/2015/127010
DO - 10.1155/2015/127010
M3 - Article
C2 - 25767561
AN - SCOPUS:84924118440
VL - 2015
JO - Computational and Mathematical Methods in Medicine
JF - Computational and Mathematical Methods in Medicine
SN - 1748-670X
M1 - 127010
ER -