Details
| Original language | English |
|---|---|
| Pages (from-to) | 1167-90 |
| Number of pages | 24 |
| Journal | Molecular plant |
| Volume | 7 |
| Issue number | 7 |
| Publication status | Published - Jul 2014 |
| Externally published | Yes |
Abstract
Plastid-to-nucleus signaling is essential for the coordination and adjustment of cellular metabolism in response to environmental and developmental cues of plant cells. A variety of operational retrograde signaling pathways have been described that are thought to be triggered by reactive oxygen species, photosynthesis redox imbalance, tetrapyrrole intermediates, and other metabolic traits. Here we report a meta-analysis based on transcriptome and protein interaction data. Comparing the output of these pathways reveals the commonalities and peculiarities stimulated by six different sources impinging on operational retrograde signaling. Our study provides novel insights into the interplay of these pathways, supporting the existence of an as-yet unknown core response module of genes being regulated under all conditions tested. Our analysis further highlights affiliated regulatory cis-elements and classifies abscisic acid and auxin-based signaling as secondary components involved in the response cascades following a plastidial signal. Our study provides a global analysis of structure and interfaces of different pathways involved in plastid-to-nucleus signaling and a new view on this complex cellular communication network.
Keywords
- Abscisic Acid/metabolism, Arabidopsis/cytology, Carbohydrate Metabolism, Gene Expression Profiling, Genes, Plant/genetics, MicroRNAs/genetics, Molecular Sequence Data, Plastids/genetics, Protein Interaction Mapping, Reactive Oxygen Species/metabolism, Regulatory Sequences, Nucleic Acid, Signal Transduction, Systems Biology
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In: Molecular plant, Vol. 7, No. 7, 07.2014, p. 1167-90.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Meta-analysis of retrograde signaling in Arabidopsis thaliana reveals a core module of genes embedded in complex cellular signaling networks
AU - Gläßer, Christine
AU - Haberer, Georg
AU - Finkemeier, Iris
AU - Pfannschmidt, Thomas
AU - Kleine, Tatjana
AU - Leister, Dario
AU - Dietz, Karl-Josef
AU - Häusler, Rainer Erich
AU - Grimm, Bernhard
AU - Mayer, Klaus Franz Xaver
N1 - © The Author 2014. Published by the Molecular Plant Shanghai Editorial Office in association with Oxford University Press on behalf of CSPB and IPPE, SIBS, CAS.
PY - 2014/7
Y1 - 2014/7
N2 - Plastid-to-nucleus signaling is essential for the coordination and adjustment of cellular metabolism in response to environmental and developmental cues of plant cells. A variety of operational retrograde signaling pathways have been described that are thought to be triggered by reactive oxygen species, photosynthesis redox imbalance, tetrapyrrole intermediates, and other metabolic traits. Here we report a meta-analysis based on transcriptome and protein interaction data. Comparing the output of these pathways reveals the commonalities and peculiarities stimulated by six different sources impinging on operational retrograde signaling. Our study provides novel insights into the interplay of these pathways, supporting the existence of an as-yet unknown core response module of genes being regulated under all conditions tested. Our analysis further highlights affiliated regulatory cis-elements and classifies abscisic acid and auxin-based signaling as secondary components involved in the response cascades following a plastidial signal. Our study provides a global analysis of structure and interfaces of different pathways involved in plastid-to-nucleus signaling and a new view on this complex cellular communication network.
AB - Plastid-to-nucleus signaling is essential for the coordination and adjustment of cellular metabolism in response to environmental and developmental cues of plant cells. A variety of operational retrograde signaling pathways have been described that are thought to be triggered by reactive oxygen species, photosynthesis redox imbalance, tetrapyrrole intermediates, and other metabolic traits. Here we report a meta-analysis based on transcriptome and protein interaction data. Comparing the output of these pathways reveals the commonalities and peculiarities stimulated by six different sources impinging on operational retrograde signaling. Our study provides novel insights into the interplay of these pathways, supporting the existence of an as-yet unknown core response module of genes being regulated under all conditions tested. Our analysis further highlights affiliated regulatory cis-elements and classifies abscisic acid and auxin-based signaling as secondary components involved in the response cascades following a plastidial signal. Our study provides a global analysis of structure and interfaces of different pathways involved in plastid-to-nucleus signaling and a new view on this complex cellular communication network.
KW - Abscisic Acid/metabolism
KW - Arabidopsis/cytology
KW - Carbohydrate Metabolism
KW - Gene Expression Profiling
KW - Genes, Plant/genetics
KW - MicroRNAs/genetics
KW - Molecular Sequence Data
KW - Plastids/genetics
KW - Protein Interaction Mapping
KW - Reactive Oxygen Species/metabolism
KW - Regulatory Sequences, Nucleic Acid
KW - Signal Transduction
KW - Systems Biology
U2 - 10.1093/mp/ssu042
DO - 10.1093/mp/ssu042
M3 - Article
C2 - 24719466
VL - 7
SP - 1167
EP - 1190
JO - Molecular plant
JF - Molecular plant
SN - 1674-2052
IS - 7
ER -