Details
| Translated title of the contribution | Vereinigung von chemischer Synthese und Biosynthese: ein neues Kapitel in der Totalsynthese von Naturstoffen und Naturstoffbibliotheken |
|---|---|
| Original language | English |
| Pages (from-to) | 4012-4022 |
| Number of pages | 11 |
| Journal | Angewandte Chemie |
| Volume | 51 |
| Issue number | 17 |
| Publication status | Published - 22 Mar 2012 |
Abstract
Taking it easy: Natural product synthesis is a stressful task. Exploiting the understanding of biosynthetic pathways and implementing genetic engineering into the synthetic chemist's portfolio paves the way for new alternatives for natural product synthesis. This Minireview describes "hybrid" strategies of organic synthesis and biosynthesis that result in facile access to complex natural products and libraries based on them.
Keywords
- metabolic engineering, mutasynthesis, natural products, semisynthesis, total synthesis
ASJC Scopus subject areas
- Chemical Engineering(all)
- Catalysis
- Chemistry(all)
- General Chemistry
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In: Angewandte Chemie , Vol. 51, No. 17, 22.03.2012, p. 4012-4022.
Research output: Contribution to journal › Review article › Research › peer review
}
TY - JOUR
T1 - Merging chemical synthesis and biosynthesis
T2 - A new chapter in the total synthesis of natural products and natural product libraries
AU - Kirschning, Andreas
AU - Hahn, Frank
PY - 2012/3/22
Y1 - 2012/3/22
N2 - Taking it easy: Natural product synthesis is a stressful task. Exploiting the understanding of biosynthetic pathways and implementing genetic engineering into the synthetic chemist's portfolio paves the way for new alternatives for natural product synthesis. This Minireview describes "hybrid" strategies of organic synthesis and biosynthesis that result in facile access to complex natural products and libraries based on them.
AB - Taking it easy: Natural product synthesis is a stressful task. Exploiting the understanding of biosynthetic pathways and implementing genetic engineering into the synthetic chemist's portfolio paves the way for new alternatives for natural product synthesis. This Minireview describes "hybrid" strategies of organic synthesis and biosynthesis that result in facile access to complex natural products and libraries based on them.
KW - metabolic engineering
KW - mutasynthesis
KW - natural products
KW - semisynthesis
KW - total synthesis
UR - http://www.scopus.com/inward/record.url?scp=84859957277&partnerID=8YFLogxK
U2 - 10.1002/anie.201107386
DO - 10.1002/anie.201107386
M3 - Review article
C2 - 22441812
AN - SCOPUS:84859957277
VL - 51
SP - 4012
EP - 4022
JO - Angewandte Chemie
JF - Angewandte Chemie
SN - 1433-7851
IS - 17
ER -