Details
| Original language | English |
|---|---|
| Pages (from-to) | 1436 - 1440 |
| Number of pages | 5 |
| Journal | Applied Physiology, Nutrition and Metabolism |
| Volume | 49 |
| Issue number | 10 |
| Early online date | 17 Jun 2024 |
| Publication status | Published - Oct 2024 |
Abstract
We recently explored the cardiopulmonary interactions during partial unloading of the respiratory muscles during exercise. Expanding upon this work, we present a noteworthy case study whereby we eliminated the influence of respiration on cardiac function in a conscious but mechanically ventilated human during exercise. This human was a young healthy endurance-trained male who was mechanically ventilated during semi-recumbent cycle exercise at 75 Watts (W) (~30% Wmax). During mechanically ventilated exercise, esophageal pressure was reduced to levels indistinguishable from the cardiac artefact which led to a 94% reduction in the work of breathing. The reduction in respiratory pressures and respiratory muscle work led to a decrease in cardiac output (-6%), which was due to a reduction in stroke volume (-13%), left ventricular end-diastolic volume (-15%) and left-ventricular end-systolic volume (-17%) that was not compensated for by heart rate. Our case highlights the influence of extreme mechanical ventilation on cardiac function while noting the possible presence of a maximal physiological limit to which respiration (and its associated pressures) impacts cardiac function when the work of breathing is maximally reduced.
Keywords
- cardiac output, echocardiography, exercise, heart-lung interactions, intrathoracic pressure, proportional assist ventilation
ASJC Scopus subject areas
- Medicine(all)
- Physiology (medical)
- Nursing(all)
- Nutrition and Dietetics
- Biochemistry, Genetics and Molecular Biology(all)
- Physiology
- Medicine(all)
- Endocrinology, Diabetes and Metabolism
Sustainable Development Goals
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In: Applied Physiology, Nutrition and Metabolism, Vol. 49, No. 10, 10.2024, p. 1436 - 1440.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Mechanical ventilation in a conscious male during exercise
T2 - A case report
AU - Angus, Sarah Anne
AU - Taylor, Joshua L
AU - Mann, Leah
AU - Williams, Alex
AU - Stöhr, Eric J
AU - Au, Jason S
AU - Sheel, Andrew William
AU - Dominelli, Paolo B
PY - 2024/10
Y1 - 2024/10
N2 - We recently explored the cardiopulmonary interactions during partial unloading of the respiratory muscles during exercise. Expanding upon this work, we present a noteworthy case study whereby we eliminated the influence of respiration on cardiac function in a conscious but mechanically ventilated human during exercise. This human was a young healthy endurance-trained male who was mechanically ventilated during semi-recumbent cycle exercise at 75 Watts (W) (~30% Wmax). During mechanically ventilated exercise, esophageal pressure was reduced to levels indistinguishable from the cardiac artefact which led to a 94% reduction in the work of breathing. The reduction in respiratory pressures and respiratory muscle work led to a decrease in cardiac output (-6%), which was due to a reduction in stroke volume (-13%), left ventricular end-diastolic volume (-15%) and left-ventricular end-systolic volume (-17%) that was not compensated for by heart rate. Our case highlights the influence of extreme mechanical ventilation on cardiac function while noting the possible presence of a maximal physiological limit to which respiration (and its associated pressures) impacts cardiac function when the work of breathing is maximally reduced.
AB - We recently explored the cardiopulmonary interactions during partial unloading of the respiratory muscles during exercise. Expanding upon this work, we present a noteworthy case study whereby we eliminated the influence of respiration on cardiac function in a conscious but mechanically ventilated human during exercise. This human was a young healthy endurance-trained male who was mechanically ventilated during semi-recumbent cycle exercise at 75 Watts (W) (~30% Wmax). During mechanically ventilated exercise, esophageal pressure was reduced to levels indistinguishable from the cardiac artefact which led to a 94% reduction in the work of breathing. The reduction in respiratory pressures and respiratory muscle work led to a decrease in cardiac output (-6%), which was due to a reduction in stroke volume (-13%), left ventricular end-diastolic volume (-15%) and left-ventricular end-systolic volume (-17%) that was not compensated for by heart rate. Our case highlights the influence of extreme mechanical ventilation on cardiac function while noting the possible presence of a maximal physiological limit to which respiration (and its associated pressures) impacts cardiac function when the work of breathing is maximally reduced.
KW - cardiac output
KW - echocardiography
KW - exercise
KW - heart-lung interactions
KW - intrathoracic pressure
KW - proportional assist ventilation
UR - http://www.scopus.com/inward/record.url?scp=85205604590&partnerID=8YFLogxK
U2 - 10.1139/apnm-2024-0100
DO - 10.1139/apnm-2024-0100
M3 - Article
C2 - 38885533
VL - 49
SP - 1436
EP - 1440
JO - Applied Physiology, Nutrition and Metabolism
JF - Applied Physiology, Nutrition and Metabolism
SN - 1715-5312
IS - 10
ER -