Details
| Original language | English |
|---|---|
| Pages (from-to) | 8458-8467 |
| Number of pages | 10 |
| Journal | Industrial and Engineering Chemistry Research |
| Volume | 44 |
| Issue number | 23 |
| Publication status | Published - 5 May 2005 |
Abstract
The introduction of continuous-flow techniques in the field of solid-phase assisted organic synthesis requires appropriate reactors. These flow reactors must fulfill several requirements, ranging from aspects of chemical reaction engineering and cost-effective manufacturing to specific conditions in organic synthetic methods. The successful manufacturing of such flow reactors requires the interdisciplinary cooperation of different research teams, complementing each other. In this paper, the development of the PASSflow reactor is described, which covers aspects of mechanical reactor design based on chemical reaction engineering concepts. In addition, the utilization of these optimized reactors in palladium(0)-catalyzed Suzuki-Miyaura cross-coupling reactions is presented.
ASJC Scopus subject areas
- Chemistry(all)
- General Chemistry
- Chemical Engineering(all)
- General Chemical Engineering
- Engineering(all)
- Industrial and Manufacturing Engineering
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In: Industrial and Engineering Chemistry Research, Vol. 44, No. 23, 05.05.2005, p. 8458-8467.
Research output: Contribution to journal › Review article › Research › peer review
}
TY - JOUR
T1 - Manufacturing and construction of PASSflow flow reactors and their utilization in Suzuki-Miyaura cross-coupling reactions
AU - Kunz, Ulrich
AU - Schönfeld, Hagen
AU - Solodenko, Wladimir
AU - Jas, Gerhard
AU - Kirschning, Andreas
PY - 2005/5/5
Y1 - 2005/5/5
N2 - The introduction of continuous-flow techniques in the field of solid-phase assisted organic synthesis requires appropriate reactors. These flow reactors must fulfill several requirements, ranging from aspects of chemical reaction engineering and cost-effective manufacturing to specific conditions in organic synthetic methods. The successful manufacturing of such flow reactors requires the interdisciplinary cooperation of different research teams, complementing each other. In this paper, the development of the PASSflow reactor is described, which covers aspects of mechanical reactor design based on chemical reaction engineering concepts. In addition, the utilization of these optimized reactors in palladium(0)-catalyzed Suzuki-Miyaura cross-coupling reactions is presented.
AB - The introduction of continuous-flow techniques in the field of solid-phase assisted organic synthesis requires appropriate reactors. These flow reactors must fulfill several requirements, ranging from aspects of chemical reaction engineering and cost-effective manufacturing to specific conditions in organic synthetic methods. The successful manufacturing of such flow reactors requires the interdisciplinary cooperation of different research teams, complementing each other. In this paper, the development of the PASSflow reactor is described, which covers aspects of mechanical reactor design based on chemical reaction engineering concepts. In addition, the utilization of these optimized reactors in palladium(0)-catalyzed Suzuki-Miyaura cross-coupling reactions is presented.
UR - http://www.scopus.com/inward/record.url?scp=28444497724&partnerID=8YFLogxK
U2 - 10.1021/ie048891x
DO - 10.1021/ie048891x
M3 - Review article
AN - SCOPUS:28444497724
VL - 44
SP - 8458
EP - 8467
JO - Industrial and Engineering Chemistry Research
JF - Industrial and Engineering Chemistry Research
SN - 0888-5885
IS - 23
ER -