Details
| Original language | English |
|---|---|
| Title of host publication | Natural Products |
| Subtitle of host publication | Discourse, Diversity, and Design |
| Publisher | Wiley-Blackwell |
| Pages | 245-260 |
| Number of pages | 16 |
| ISBN (electronic) | 9781118794623 |
| ISBN (print) | 9781118298060 |
| Publication status | Published - 5 May 2014 |
| Externally published | Yes |
Abstract
Annotation of fungal genes is advanced enough to differentiate primary and secondary metabolic genes. In the case of secondary metabolism, which is the focus of this chapter, it is generally observed that genes responsible for natural product biosynthesis are clustered, as observed in prokaryotes. Molecular methods in fungi are not as advanced as in bacteria, although recent, rapid developments in the area of gene knockout, gene silencing, and heterologous expression have accelerated discovery and exploitation of fungal natural product gene clusters. New concepts surrounding synthetic biology are being applied to fungal systems and the prospects for rapid and effective exploitation of fungal secondary metabolism. This chapter focuses on a relatively small range of cases where this has been begun or partially achieved. It has recently emerged that epigenetic processes can also dramatically influence the secondary metabolite profiles of many fungi. This edition first published 2014
Keywords
- Epigenetic remodeling, Fungal natural product pathways, Gene cluster expression, Gene knockout, Gene silencing, Heterologous expression, Mutasynthesis, Precursor-directed biosynthesis, Yeast expression
ASJC Scopus subject areas
- Immunology and Microbiology(all)
- General Immunology and Microbiology
Cite this
- Standard
- Harvard
- Apa
- Vancouver
- BibTeX
- RIS
Natural Products: Discourse, Diversity, and Design. Wiley-Blackwell, 2014. p. 245-260.
Research output: Chapter in book/report/conference proceeding › Contribution to book/anthology › Research › peer review
}
TY - CHAP
T1 - Manipulation of Fungal Natural Product Pathways
AU - Cox, Russell J.
AU - Williams, Katherine
PY - 2014/5/5
Y1 - 2014/5/5
N2 - Annotation of fungal genes is advanced enough to differentiate primary and secondary metabolic genes. In the case of secondary metabolism, which is the focus of this chapter, it is generally observed that genes responsible for natural product biosynthesis are clustered, as observed in prokaryotes. Molecular methods in fungi are not as advanced as in bacteria, although recent, rapid developments in the area of gene knockout, gene silencing, and heterologous expression have accelerated discovery and exploitation of fungal natural product gene clusters. New concepts surrounding synthetic biology are being applied to fungal systems and the prospects for rapid and effective exploitation of fungal secondary metabolism. This chapter focuses on a relatively small range of cases where this has been begun or partially achieved. It has recently emerged that epigenetic processes can also dramatically influence the secondary metabolite profiles of many fungi. This edition first published 2014
AB - Annotation of fungal genes is advanced enough to differentiate primary and secondary metabolic genes. In the case of secondary metabolism, which is the focus of this chapter, it is generally observed that genes responsible for natural product biosynthesis are clustered, as observed in prokaryotes. Molecular methods in fungi are not as advanced as in bacteria, although recent, rapid developments in the area of gene knockout, gene silencing, and heterologous expression have accelerated discovery and exploitation of fungal natural product gene clusters. New concepts surrounding synthetic biology are being applied to fungal systems and the prospects for rapid and effective exploitation of fungal secondary metabolism. This chapter focuses on a relatively small range of cases where this has been begun or partially achieved. It has recently emerged that epigenetic processes can also dramatically influence the secondary metabolite profiles of many fungi. This edition first published 2014
KW - Epigenetic remodeling
KW - Fungal natural product pathways
KW - Gene cluster expression
KW - Gene knockout
KW - Gene silencing
KW - Heterologous expression
KW - Mutasynthesis
KW - Precursor-directed biosynthesis
KW - Yeast expression
UR - http://www.scopus.com/inward/record.url?scp=84926435456&partnerID=8YFLogxK
U2 - 10.1002/9781118794623.ch13
DO - 10.1002/9781118794623.ch13
M3 - Contribution to book/anthology
AN - SCOPUS:84926435456
SN - 9781118298060
SP - 245
EP - 260
BT - Natural Products
PB - Wiley-Blackwell
ER -