Details
| Original language | English |
|---|---|
| Pages (from-to) | 128-157 |
| Number of pages | 30 |
| Journal | Natural product reports |
| Volume | 40 |
| Issue number | 1 |
| Publication status | Published - 21 Sept 2022 |
Abstract
Covering: up to early 2022 Maleidrides are a family of polyketide-based dimeric natural products isolated from fungi. Many maleidrides possess significant bioactivities, making them attractive pharmaceutical or agrochemical lead compounds. Their unusual biosynthetic pathways have fascinated scientists for decades, with recent advances in our bioinformatic and enzymatic understanding providing further insights into their construction. However, many intriguing questions remain, including exactly how the enzymatic dimerisation, which creates the diverse core structure of the maleidrides, is controlled. This review will explore the literature from the initial isolation of maleidride compounds in the 1930s, through the first full structural elucidation in the 1960s, to the most recent in vivo, in vitro, and in silico analyses.
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Biochemistry
- Pharmacology, Toxicology and Pharmaceutics(all)
- Drug Discovery
- Chemistry(all)
- Organic Chemistry
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In: Natural product reports, Vol. 40, No. 1, 21.09.2022, p. 128-157.
Research output: Contribution to journal › Review article › Research › peer review
}
TY - JOUR
T1 - Maleidride biosynthesis
T2 - construction of dimeric anhydrides - more than just heads or tails
AU - Williams, Katherine
AU - Szwalbe, Agnieszka J.
AU - de Mattos-Shipley, Kate M.J.
AU - Bailey, Andy M.
AU - Cox, Russell J.
AU - Willis, Christine L.
N1 - Funding Information: We would like to thank the MRC for funding KW and KMJdMS (MR/N029909/1), and the BBSRC and Syngenta for funding AJS (BB/J006289/1). We would like to thank Dr Claudio Greco for useful discussions on this work.
PY - 2022/9/21
Y1 - 2022/9/21
N2 - Covering: up to early 2022 Maleidrides are a family of polyketide-based dimeric natural products isolated from fungi. Many maleidrides possess significant bioactivities, making them attractive pharmaceutical or agrochemical lead compounds. Their unusual biosynthetic pathways have fascinated scientists for decades, with recent advances in our bioinformatic and enzymatic understanding providing further insights into their construction. However, many intriguing questions remain, including exactly how the enzymatic dimerisation, which creates the diverse core structure of the maleidrides, is controlled. This review will explore the literature from the initial isolation of maleidride compounds in the 1930s, through the first full structural elucidation in the 1960s, to the most recent in vivo, in vitro, and in silico analyses.
AB - Covering: up to early 2022 Maleidrides are a family of polyketide-based dimeric natural products isolated from fungi. Many maleidrides possess significant bioactivities, making them attractive pharmaceutical or agrochemical lead compounds. Their unusual biosynthetic pathways have fascinated scientists for decades, with recent advances in our bioinformatic and enzymatic understanding providing further insights into their construction. However, many intriguing questions remain, including exactly how the enzymatic dimerisation, which creates the diverse core structure of the maleidrides, is controlled. This review will explore the literature from the initial isolation of maleidride compounds in the 1930s, through the first full structural elucidation in the 1960s, to the most recent in vivo, in vitro, and in silico analyses.
UR - http://www.scopus.com/inward/record.url?scp=85139256594&partnerID=8YFLogxK
U2 - 10.1039/d2np00041e
DO - 10.1039/d2np00041e
M3 - Review article
AN - SCOPUS:85139256594
VL - 40
SP - 128
EP - 157
JO - Natural product reports
JF - Natural product reports
SN - 0265-0568
IS - 1
ER -