Details
| Original language | English |
|---|---|
| Pages (from-to) | 1788-1796 |
| Number of pages | 9 |
| Journal | European Radiology |
| Volume | 21 |
| Issue number | 8 |
| Early online date | 15 Mar 2011 |
| Publication status | Published - Aug 2011 |
Abstract
Objectives To evaluate the applicability of 4D phase contrast (4D PC) MR imaging in the assessment of cerebrospinal fluid dynamics in healthy volunteers and patients with lesions at the craniocervical junction or the cervical spinal canal. Methods Ten healthy volunteers and four patients with lesions including Chiari I malformation and cervical canal stenoses were examined by a cardiac-gated 4D PC imaging sequence on 1.5T MRI. Phase contrast images were postprocessed allowing for flow quantification and flow pathline visualisation. Velocity data were compared with conventional axial 2D phase contrast images. Results The 4D PC sequence allowed for flow quantification and visualisation in all individuals. Bland-Altman analysis showed good agreement of 2D and 4D PC velocity data. In healthy volunteers, CSF flow was homogeneously distributed in the anterior and anterolateral subarachnoid space with the flow directed caudally during systole and cranially during diastole. Flow velocities were closely related to the width of the subarachnoid space. Patients showed grossly altered CSF flow patterns with formation of flow jets with increased flow velocities. Conclusions 4D PC MR imaging allows for a detailed assessment of CSF flow dynamics helping to distinguish physiological from complex pathological flow patterns at the craniocervical junction and the cervical spine.
Keywords
- Cerebrospinal fluid, Cervical canal stenosis, Chiari malformation, Flow-sensitive 4D MRI, Syringomyelia
ASJC Scopus subject areas
- Medicine(all)
- Radiology Nuclear Medicine and imaging
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In: European Radiology, Vol. 21, No. 8, 08.2011, p. 1788-1796.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Magnetic resonance 4D flow characteristics of cerebrospinal fluid at the craniocervical junction and the cervical spinal canal
AU - Bunck, Alexander C.
AU - Kröger, Jan Robert
AU - Jüttner, Alena
AU - Brentrup, Angela
AU - Fiedler, Barbara
AU - Schaarschmidt, Frank
AU - Crelier, Gerard R.
AU - Schwindt, Wolfram
AU - Heindel, Walter
AU - Niederstadt, Thomas
AU - Maintz, David
PY - 2011/8
Y1 - 2011/8
N2 - Objectives To evaluate the applicability of 4D phase contrast (4D PC) MR imaging in the assessment of cerebrospinal fluid dynamics in healthy volunteers and patients with lesions at the craniocervical junction or the cervical spinal canal. Methods Ten healthy volunteers and four patients with lesions including Chiari I malformation and cervical canal stenoses were examined by a cardiac-gated 4D PC imaging sequence on 1.5T MRI. Phase contrast images were postprocessed allowing for flow quantification and flow pathline visualisation. Velocity data were compared with conventional axial 2D phase contrast images. Results The 4D PC sequence allowed for flow quantification and visualisation in all individuals. Bland-Altman analysis showed good agreement of 2D and 4D PC velocity data. In healthy volunteers, CSF flow was homogeneously distributed in the anterior and anterolateral subarachnoid space with the flow directed caudally during systole and cranially during diastole. Flow velocities were closely related to the width of the subarachnoid space. Patients showed grossly altered CSF flow patterns with formation of flow jets with increased flow velocities. Conclusions 4D PC MR imaging allows for a detailed assessment of CSF flow dynamics helping to distinguish physiological from complex pathological flow patterns at the craniocervical junction and the cervical spine.
AB - Objectives To evaluate the applicability of 4D phase contrast (4D PC) MR imaging in the assessment of cerebrospinal fluid dynamics in healthy volunteers and patients with lesions at the craniocervical junction or the cervical spinal canal. Methods Ten healthy volunteers and four patients with lesions including Chiari I malformation and cervical canal stenoses were examined by a cardiac-gated 4D PC imaging sequence on 1.5T MRI. Phase contrast images were postprocessed allowing for flow quantification and flow pathline visualisation. Velocity data were compared with conventional axial 2D phase contrast images. Results The 4D PC sequence allowed for flow quantification and visualisation in all individuals. Bland-Altman analysis showed good agreement of 2D and 4D PC velocity data. In healthy volunteers, CSF flow was homogeneously distributed in the anterior and anterolateral subarachnoid space with the flow directed caudally during systole and cranially during diastole. Flow velocities were closely related to the width of the subarachnoid space. Patients showed grossly altered CSF flow patterns with formation of flow jets with increased flow velocities. Conclusions 4D PC MR imaging allows for a detailed assessment of CSF flow dynamics helping to distinguish physiological from complex pathological flow patterns at the craniocervical junction and the cervical spine.
KW - Cerebrospinal fluid
KW - Cervical canal stenosis
KW - Chiari malformation
KW - Flow-sensitive 4D MRI
KW - Syringomyelia
UR - http://www.scopus.com/inward/record.url?scp=80052654098&partnerID=8YFLogxK
U2 - 10.1007/s00330-011-2105-7
DO - 10.1007/s00330-011-2105-7
M3 - Article
C2 - 21404133
AN - SCOPUS:80052654098
VL - 21
SP - 1788
EP - 1796
JO - European Radiology
JF - European Radiology
SN - 0938-7994
IS - 8
ER -