Details
| Original language | English |
|---|---|
| Pages (from-to) | 5645-5650 |
| Number of pages | 6 |
| Journal | Advanced materials |
| Volume | 23 |
| Issue number | 47 |
| Publication status | Published - 18 Nov 2011 |
| Externally published | Yes |
Abstract
Superparamagnetic nanocarriers with tunable pH dependence of the surface charge are designed by a simple co-precipitation method. By exploiting electrostatic interactions, cationic or anionic payloads can be adsorbed and desorbed depending on the pH. On three different resulting nanocarrier systems, experiments of loading and release of gold nanoparticles as well as effective siRNA loading and in vitro delivery on human cells are performed.
Keywords
- gold nanoparticles, magnetic nanobeads, pH-responsive materials, siRNA delivery, superparamagnetic nanocarriers
ASJC Scopus subject areas
- Materials Science(all)
- General Materials Science
- Engineering(all)
- Mechanics of Materials
- Engineering(all)
- Mechanical Engineering
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In: Advanced materials, Vol. 23, No. 47, 18.11.2011, p. 5645-5650.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Magnetic Nanocarriers with Tunable pH Dependence for Controlled Loading and Release of Cationic and Anionic Payloads
AU - Bigall, Nadja C.
AU - Curcio, Alberto
AU - Leal, Manuel Pernia
AU - Falqui, Andrea
AU - Palumberi, Domenico
AU - Di Corato, Riccardo
AU - Albanesi, Ennio
AU - Cingolani, Roberto
AU - Pellegrino, Teresa
PY - 2011/11/18
Y1 - 2011/11/18
N2 - Superparamagnetic nanocarriers with tunable pH dependence of the surface charge are designed by a simple co-precipitation method. By exploiting electrostatic interactions, cationic or anionic payloads can be adsorbed and desorbed depending on the pH. On three different resulting nanocarrier systems, experiments of loading and release of gold nanoparticles as well as effective siRNA loading and in vitro delivery on human cells are performed.
AB - Superparamagnetic nanocarriers with tunable pH dependence of the surface charge are designed by a simple co-precipitation method. By exploiting electrostatic interactions, cationic or anionic payloads can be adsorbed and desorbed depending on the pH. On three different resulting nanocarrier systems, experiments of loading and release of gold nanoparticles as well as effective siRNA loading and in vitro delivery on human cells are performed.
KW - gold nanoparticles
KW - magnetic nanobeads
KW - pH-responsive materials
KW - siRNA delivery
KW - superparamagnetic nanocarriers
UR - http://www.scopus.com/inward/record.url?scp=83455163900&partnerID=8YFLogxK
U2 - 10.1002/adma.201103505
DO - 10.1002/adma.201103505
M3 - Article
C2 - 22095932
AN - SCOPUS:83455163900
VL - 23
SP - 5645
EP - 5650
JO - Advanced materials
JF - Advanced materials
SN - 0935-9648
IS - 47
ER -