Details
| Original language | English |
|---|---|
| Pages (from-to) | 355-361 |
| Number of pages | 7 |
| Journal | IEEE Journal of Electromagnetics, RF and Microwaves in Medicine and Biology |
| Volume | 5 |
| Issue number | 4 |
| Publication status | Published - 19 Mar 2021 |
Abstract
A lumped element model for cells is proposed, giving an overview of the general electrical behavior (e.g. in terms of current distribution within different cell layers) of a cell exposed to an external electric field. The aim is to provide a model which is easily adaptable to different cell types and cell sizes such that it can be used in the frame of different studies where cells are exposed to electric fields, e.g. Tumor Treating Fields, operating at frequencies around 200 kHz. Originating from the usual model of a spherical cell, an electric lumped element model is derived under consideration of the electric field distribution within a cell. Possible simplifications of the model are suggested, which are justified by consideration of electrical material properties. Lumped element parameters of the model are approximated with formulas containing only cell dimensional parameters and electrical material parameters. The lumped element model is validated on the basis of a glioblastoma cell model with two different nuclei sizes. The proposed lumped element model with the according formulas for the lumped element parameters is easily adaptable to different cell types and cell sizes. It leads to a sufficient approximation of the general electrical behavior of cells in terms of current distribution and general frequency behavior in frequency ranges up to several hundreds of megahertz. The model is an easy to handle electrical description of a biological cell.
Keywords
- Adaptation models, Biological system modeling, Capacitance, Cells (biology), Electric fields, Impedance, Resistance, electrical treatment of cells, tumor treating fields, lumped element model of biological cells, Biological cells
ASJC Scopus subject areas
- Physics and Astronomy(all)
- Instrumentation
- Physics and Astronomy(all)
- Radiation
- Medicine(all)
- Radiology Nuclear Medicine and imaging
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In: IEEE Journal of Electromagnetics, RF and Microwaves in Medicine and Biology, Vol. 5, No. 4, 19.03.2021, p. 355-361.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Lumped Element Model of Spherical Cells Exposed to an External Electric Field
AU - Harke, Saba
AU - Manteuffel, Dirk
PY - 2021/3/19
Y1 - 2021/3/19
N2 - A lumped element model for cells is proposed, giving an overview of the general electrical behavior (e.g. in terms of current distribution within different cell layers) of a cell exposed to an external electric field. The aim is to provide a model which is easily adaptable to different cell types and cell sizes such that it can be used in the frame of different studies where cells are exposed to electric fields, e.g. Tumor Treating Fields, operating at frequencies around 200 kHz. Originating from the usual model of a spherical cell, an electric lumped element model is derived under consideration of the electric field distribution within a cell. Possible simplifications of the model are suggested, which are justified by consideration of electrical material properties. Lumped element parameters of the model are approximated with formulas containing only cell dimensional parameters and electrical material parameters. The lumped element model is validated on the basis of a glioblastoma cell model with two different nuclei sizes. The proposed lumped element model with the according formulas for the lumped element parameters is easily adaptable to different cell types and cell sizes. It leads to a sufficient approximation of the general electrical behavior of cells in terms of current distribution and general frequency behavior in frequency ranges up to several hundreds of megahertz. The model is an easy to handle electrical description of a biological cell.
AB - A lumped element model for cells is proposed, giving an overview of the general electrical behavior (e.g. in terms of current distribution within different cell layers) of a cell exposed to an external electric field. The aim is to provide a model which is easily adaptable to different cell types and cell sizes such that it can be used in the frame of different studies where cells are exposed to electric fields, e.g. Tumor Treating Fields, operating at frequencies around 200 kHz. Originating from the usual model of a spherical cell, an electric lumped element model is derived under consideration of the electric field distribution within a cell. Possible simplifications of the model are suggested, which are justified by consideration of electrical material properties. Lumped element parameters of the model are approximated with formulas containing only cell dimensional parameters and electrical material parameters. The lumped element model is validated on the basis of a glioblastoma cell model with two different nuclei sizes. The proposed lumped element model with the according formulas for the lumped element parameters is easily adaptable to different cell types and cell sizes. It leads to a sufficient approximation of the general electrical behavior of cells in terms of current distribution and general frequency behavior in frequency ranges up to several hundreds of megahertz. The model is an easy to handle electrical description of a biological cell.
KW - Adaptation models
KW - Biological system modeling
KW - Capacitance
KW - Cells (biology)
KW - Electric fields
KW - Impedance
KW - Resistance
KW - electrical treatment of cells
KW - tumor treating fields
KW - lumped element model of biological cells
KW - Biological cells
UR - http://www.scopus.com/inward/record.url?scp=85103240327&partnerID=8YFLogxK
U2 - 10.1109/jerm.2021.3067596
DO - 10.1109/jerm.2021.3067596
M3 - Article
AN - SCOPUS:85103240327
VL - 5
SP - 355
EP - 361
JO - IEEE Journal of Electromagnetics, RF and Microwaves in Medicine and Biology
JF - IEEE Journal of Electromagnetics, RF and Microwaves in Medicine and Biology
IS - 4
ER -