Details
| Original language | English |
|---|---|
| Article number | 141193 |
| Journal | Food Chemistry |
| Volume | 463 |
| Issue number | 2 |
| Early online date | 11 Sept 2024 |
| Publication status | E-pub ahead of print - 11 Sept 2024 |
Abstract
Despite its many beneficial effects, pharmaceutical applications of curcumin (CUR) are limited due to its chemical instability, low solubility/absorption and weak bioavailability. Recent advances in nanotechnology have enabled the development of CUR-loaded nanodelivery systems to tackle those issues. Within many different nanocarriers developed for CUR up to date, lipid-based nanocarriers (LBNs) are among the most extensively studied systems. LBNs such as nanoemulsions, solid lipid carriers, nanostructured phospholipid/surfactant carriers are shown to be potential delivery systems capable of improving the solubility, bioavailability, and chemical stability of CUR. The particle characteristics, stability, bioavailability, and release properties of CUR-loaded LBNs can be tailored via optimizing the formulation and processing parameters. This paper reviews the most recent studies on the development of various CUR-loaded LBNs. Approaches to the improvement of CUR bioavailability and release characteristics of LBNs are discussed. Furthermore, challenges in the development of CUR-loaded LBNs and their potential applications are presented.
Keywords
- Curcumin, Encapsulation, Lipid nanoparticles, Nanocarriers, Nanoemulsions
ASJC Scopus subject areas
- Chemistry(all)
- Analytical Chemistry
- Agricultural and Biological Sciences(all)
- Food Science
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In: Food Chemistry, Vol. 463, No. 2, 141193, 15.01.2025.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Lipid-based nanodelivery systems of curcumin: Recent advances, approaches, and applications
AU - Can Karaca, Asli
AU - Rezaei, Atefe
AU - Qamar, Muhammad
AU - Assadpour, Elham
AU - Esatbeyoglu, Tuba
AU - Jafari, Seid Mahdi
N1 - Copyright © 2024 Elsevier Ltd. All rights reserved. Publisher Copyright: © 2024 Elsevier Ltd
PY - 2024/9/11
Y1 - 2024/9/11
N2 - Despite its many beneficial effects, pharmaceutical applications of curcumin (CUR) are limited due to its chemical instability, low solubility/absorption and weak bioavailability. Recent advances in nanotechnology have enabled the development of CUR-loaded nanodelivery systems to tackle those issues. Within many different nanocarriers developed for CUR up to date, lipid-based nanocarriers (LBNs) are among the most extensively studied systems. LBNs such as nanoemulsions, solid lipid carriers, nanostructured phospholipid/surfactant carriers are shown to be potential delivery systems capable of improving the solubility, bioavailability, and chemical stability of CUR. The particle characteristics, stability, bioavailability, and release properties of CUR-loaded LBNs can be tailored via optimizing the formulation and processing parameters. This paper reviews the most recent studies on the development of various CUR-loaded LBNs. Approaches to the improvement of CUR bioavailability and release characteristics of LBNs are discussed. Furthermore, challenges in the development of CUR-loaded LBNs and their potential applications are presented.
AB - Despite its many beneficial effects, pharmaceutical applications of curcumin (CUR) are limited due to its chemical instability, low solubility/absorption and weak bioavailability. Recent advances in nanotechnology have enabled the development of CUR-loaded nanodelivery systems to tackle those issues. Within many different nanocarriers developed for CUR up to date, lipid-based nanocarriers (LBNs) are among the most extensively studied systems. LBNs such as nanoemulsions, solid lipid carriers, nanostructured phospholipid/surfactant carriers are shown to be potential delivery systems capable of improving the solubility, bioavailability, and chemical stability of CUR. The particle characteristics, stability, bioavailability, and release properties of CUR-loaded LBNs can be tailored via optimizing the formulation and processing parameters. This paper reviews the most recent studies on the development of various CUR-loaded LBNs. Approaches to the improvement of CUR bioavailability and release characteristics of LBNs are discussed. Furthermore, challenges in the development of CUR-loaded LBNs and their potential applications are presented.
KW - Curcumin
KW - Encapsulation
KW - Lipid nanoparticles
KW - Nanocarriers
KW - Nanoemulsions
UR - http://www.scopus.com/inward/record.url?scp=85203640394&partnerID=8YFLogxK
U2 - 10.1016/j.foodchem.2024.141193
DO - 10.1016/j.foodchem.2024.141193
M3 - Article
C2 - 39276542
VL - 463
JO - Food Chemistry
JF - Food Chemistry
SN - 0308-8146
IS - 2
M1 - 141193
ER -