Details
| Original language | English |
|---|---|
| Pages (from-to) | H633-H644 |
| Journal | American Journal of Physiology - Heart and Circulatory Physiology |
| Volume | 311 |
| Issue number | 3 |
| Early online date | Sept 2016 |
| Publication status | Published - Sept 2016 |
| Externally published | Yes |
Abstract
The anatomy of the adult human left ven tricle (LV) is the result of its complex interaction with its environment. From the fetal to the neonatal to the adult form, the human LV undergoes an anatomical transformation that finally results in the most complex of the four cardiac chambers. In its adult form, the human LV consists of two muscular helixes that surround the midventricular circumferential layer of muscle fibers. Contraction of these endocardial and epicardial helixes results in a twisting motion that is thought to minimize the transmural stress of the LV muscle. In the healthy myocardium, the LV twist response to stimuli that alter preload, afterload, or contractility has been described and is deemed relatively consistent and predictable. Conversely, the LV twist response in patient populations appears to be a little more variable and less predictable, yet it has revealed important insight into the effect of cardiovascular disease on LV mechanical function. This review discusses important methodological aspects of assessing LV twist and evaluates the LV twist responses to the main physiological and pathophysiological states. It is concluded that correct assessment of LV twist mechanics holds significant potential to advance our understanding of LV function in human health and cardiovascular disease.
Keywords
- Cardiovascular disease, Deformation, Exercise, Torsion, Twist
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Physiology
- Medicine(all)
- Cardiology and Cardiovascular Medicine
- Medicine(all)
- Physiology (medical)
Sustainable Development Goals
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In: American Journal of Physiology - Heart and Circulatory Physiology, Vol. 311, No. 3, 09.2016, p. H633-H644.
Research output: Contribution to journal › Review article › Research › peer review
}
TY - JOUR
T1 - Left ventricular twist mechanics in the context of normal physiology and cardiovascular disease
T2 - a review of studies using speckle tracking echocardiography
AU - Stöhr, Eric J.
AU - Shave, Rob E.
AU - Baggish, Aaron L.
AU - Weiner, Rory B.
PY - 2016/9
Y1 - 2016/9
N2 - The anatomy of the adult human left ven tricle (LV) is the result of its complex interaction with its environment. From the fetal to the neonatal to the adult form, the human LV undergoes an anatomical transformation that finally results in the most complex of the four cardiac chambers. In its adult form, the human LV consists of two muscular helixes that surround the midventricular circumferential layer of muscle fibers. Contraction of these endocardial and epicardial helixes results in a twisting motion that is thought to minimize the transmural stress of the LV muscle. In the healthy myocardium, the LV twist response to stimuli that alter preload, afterload, or contractility has been described and is deemed relatively consistent and predictable. Conversely, the LV twist response in patient populations appears to be a little more variable and less predictable, yet it has revealed important insight into the effect of cardiovascular disease on LV mechanical function. This review discusses important methodological aspects of assessing LV twist and evaluates the LV twist responses to the main physiological and pathophysiological states. It is concluded that correct assessment of LV twist mechanics holds significant potential to advance our understanding of LV function in human health and cardiovascular disease.
AB - The anatomy of the adult human left ven tricle (LV) is the result of its complex interaction with its environment. From the fetal to the neonatal to the adult form, the human LV undergoes an anatomical transformation that finally results in the most complex of the four cardiac chambers. In its adult form, the human LV consists of two muscular helixes that surround the midventricular circumferential layer of muscle fibers. Contraction of these endocardial and epicardial helixes results in a twisting motion that is thought to minimize the transmural stress of the LV muscle. In the healthy myocardium, the LV twist response to stimuli that alter preload, afterload, or contractility has been described and is deemed relatively consistent and predictable. Conversely, the LV twist response in patient populations appears to be a little more variable and less predictable, yet it has revealed important insight into the effect of cardiovascular disease on LV mechanical function. This review discusses important methodological aspects of assessing LV twist and evaluates the LV twist responses to the main physiological and pathophysiological states. It is concluded that correct assessment of LV twist mechanics holds significant potential to advance our understanding of LV function in human health and cardiovascular disease.
KW - Cardiovascular disease
KW - Deformation
KW - Exercise
KW - Torsion
KW - Twist
UR - http://www.scopus.com/inward/record.url?scp=84984979149&partnerID=8YFLogxK
U2 - 10.1152/ajpheart.00104.2016
DO - 10.1152/ajpheart.00104.2016
M3 - Review article
C2 - 27402663
AN - SCOPUS:84984979149
VL - 311
SP - H633-H644
JO - American Journal of Physiology - Heart and Circulatory Physiology
JF - American Journal of Physiology - Heart and Circulatory Physiology
SN - 0363-6135
IS - 3
ER -