Details
| Original language | English |
|---|---|
| Pages (from-to) | 2813-2819 |
| Number of pages | 7 |
| Journal | Journal of Materials Science: Materials in Medicine |
| Volume | 23 |
| Issue number | 11 |
| Publication status | Published - 10 Aug 2012 |
| Externally published | Yes |
Abstract
Topographical cues have a significant impact on cell responses and by this means, on the fabrication of innovative implant materials. However, analysis of celltopography interactions in dependence of the surface feature dimensions is still challenging due to limitations in the fabrication technology. Here, we introduce surface structuring via picosecond laser systems, which enable a fast production of micro-sized topologies. Changes in the processing parameters further control the feature sizes of so-called spikes. Using surfaces with big and small spike-to-spikedistances for comparisons, we focussed on cell adhesion via extracellular matrix adsorption and focal adhesion complexes, morphology, localisation and proliferation of fibroblasts. The observed cell control was dependent on a turnover point related to the structure dimensions: only big spike-to-spike-distances reduced cell behaviour. Therefore, this technology offers a platform to study cell and tissue interactions with a defined microenvironment.
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Biophysics
- Chemical Engineering(all)
- Bioengineering
- Materials Science(all)
- Biomaterials
- Engineering(all)
- Biomedical Engineering
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In: Journal of Materials Science: Materials in Medicine, Vol. 23, No. 11, 10.08.2012, p. 2813-2819.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Laser-engineered topography
T2 - Correlation between structure dimensions and cell control
AU - Schlie, Sabrina
AU - Fadeeva, Elena
AU - Koroleva, Anastasia
AU - Chichkov, Boris N.
PY - 2012/8/10
Y1 - 2012/8/10
N2 - Topographical cues have a significant impact on cell responses and by this means, on the fabrication of innovative implant materials. However, analysis of celltopography interactions in dependence of the surface feature dimensions is still challenging due to limitations in the fabrication technology. Here, we introduce surface structuring via picosecond laser systems, which enable a fast production of micro-sized topologies. Changes in the processing parameters further control the feature sizes of so-called spikes. Using surfaces with big and small spike-to-spikedistances for comparisons, we focussed on cell adhesion via extracellular matrix adsorption and focal adhesion complexes, morphology, localisation and proliferation of fibroblasts. The observed cell control was dependent on a turnover point related to the structure dimensions: only big spike-to-spike-distances reduced cell behaviour. Therefore, this technology offers a platform to study cell and tissue interactions with a defined microenvironment.
AB - Topographical cues have a significant impact on cell responses and by this means, on the fabrication of innovative implant materials. However, analysis of celltopography interactions in dependence of the surface feature dimensions is still challenging due to limitations in the fabrication technology. Here, we introduce surface structuring via picosecond laser systems, which enable a fast production of micro-sized topologies. Changes in the processing parameters further control the feature sizes of so-called spikes. Using surfaces with big and small spike-to-spikedistances for comparisons, we focussed on cell adhesion via extracellular matrix adsorption and focal adhesion complexes, morphology, localisation and proliferation of fibroblasts. The observed cell control was dependent on a turnover point related to the structure dimensions: only big spike-to-spike-distances reduced cell behaviour. Therefore, this technology offers a platform to study cell and tissue interactions with a defined microenvironment.
UR - http://www.scopus.com/inward/record.url?scp=84871276466&partnerID=8YFLogxK
U2 - 10.1007/s10856-012-4737-9
DO - 10.1007/s10856-012-4737-9
M3 - Article
C2 - 22878727
AN - SCOPUS:84871276466
VL - 23
SP - 2813
EP - 2819
JO - Journal of Materials Science: Materials in Medicine
JF - Journal of Materials Science: Materials in Medicine
SN - 0957-4530
IS - 11
ER -