Details
| Original language | English |
|---|---|
| Pages (from-to) | 159-162 |
| Number of pages | 4 |
| Journal | Photonics and Nanostructures - Fundamentals and Applications |
| Volume | 9 |
| Issue number | 2 |
| Publication status | Published - Apr 2011 |
Abstract
In this study femtosecond laser systems were used for nanoengineering of special surface topographies in silicon and titanium. Besides the control of feature sizes, we demonstrated that laser structuring caused changes in material wettability due to a reduced surface contact area. These laser-engineered topographies were tested for their capability to control cellular behavior of human fibroblasts, SH-SY5Y neuroblastoma cells, and MG-63 osteoblasts. We found that fibroblasts reduced cell growth on the structures, while the other cell types proliferated at the same rate. These findings make laser-surface structuring very attractive for biomedical applications. Finally, to explain the results the correlation between topography and the biophysics of cellular adhesion, which is the key step of selective cell control, is discussed.
Keywords
- Biomedicine, Femtosecond laser, Nanoengineering, Selective cell control, Surface structuring, Water contact angle
ASJC Scopus subject areas
- Materials Science(all)
- Electronic, Optical and Magnetic Materials
- Physics and Astronomy(all)
- Atomic and Molecular Physics, and Optics
- Physics and Astronomy(all)
- Condensed Matter Physics
- Computer Science(all)
- Hardware and Architecture
- Engineering(all)
- Electrical and Electronic Engineering
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In: Photonics and Nanostructures - Fundamentals and Applications, Vol. 9, No. 2, 04.2011, p. 159-162.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Laser-based nanoengineering of surface topographies for biomedical applications
AU - Schlie, Sabrina
AU - Fadeeva, Elena
AU - Koroleva, Anastasia
AU - Ovsianikov, Aleksandr
AU - Koch, Jürgen
AU - Ngezahayo, Anaclet
AU - Chichkov, Boris N.
N1 - Funding information: This work was supported by German Research Foundation , DFG SFB599 “Sustainable Bioresorbing and Permanent Implants of Metallic and Ceramic Materials”, and DFG Transregio Project TR37 .
PY - 2011/4
Y1 - 2011/4
N2 - In this study femtosecond laser systems were used for nanoengineering of special surface topographies in silicon and titanium. Besides the control of feature sizes, we demonstrated that laser structuring caused changes in material wettability due to a reduced surface contact area. These laser-engineered topographies were tested for their capability to control cellular behavior of human fibroblasts, SH-SY5Y neuroblastoma cells, and MG-63 osteoblasts. We found that fibroblasts reduced cell growth on the structures, while the other cell types proliferated at the same rate. These findings make laser-surface structuring very attractive for biomedical applications. Finally, to explain the results the correlation between topography and the biophysics of cellular adhesion, which is the key step of selective cell control, is discussed.
AB - In this study femtosecond laser systems were used for nanoengineering of special surface topographies in silicon and titanium. Besides the control of feature sizes, we demonstrated that laser structuring caused changes in material wettability due to a reduced surface contact area. These laser-engineered topographies were tested for their capability to control cellular behavior of human fibroblasts, SH-SY5Y neuroblastoma cells, and MG-63 osteoblasts. We found that fibroblasts reduced cell growth on the structures, while the other cell types proliferated at the same rate. These findings make laser-surface structuring very attractive for biomedical applications. Finally, to explain the results the correlation between topography and the biophysics of cellular adhesion, which is the key step of selective cell control, is discussed.
KW - Biomedicine
KW - Femtosecond laser
KW - Nanoengineering
KW - Selective cell control
KW - Surface structuring
KW - Water contact angle
UR - http://www.scopus.com/inward/record.url?scp=79955463949&partnerID=8YFLogxK
U2 - 10.1016/j.photonics.2010.09.006
DO - 10.1016/j.photonics.2010.09.006
M3 - Article
AN - SCOPUS:79955463949
VL - 9
SP - 159
EP - 162
JO - Photonics and Nanostructures - Fundamentals and Applications
JF - Photonics and Nanostructures - Fundamentals and Applications
SN - 1569-4410
IS - 2
ER -