Details
| Original language | English |
|---|---|
| Pages (from-to) | 399-405 |
| Number of pages | 7 |
| Journal | Biomedizinische Technik |
| Volume | 58 |
| Issue number | 5 |
| Publication status | Published - 28 May 2013 |
| Externally published | Yes |
Abstract
The two-photon polymerization technique (2PP) uses non-linear absorption of femtosecond laser pulses to selectively polymerize photosensitive materials. 2PP has the ability to fabricate structures with a resolution from tens of micrometers down to hundreds of nanometers. Three-dimensional microstructuring by the 2PP technique provides many interesting possibilities for biomedical applications. This microstructuring technique is suitable with many biocompatible polymeric materials, such as polyethylene glycol, polylactic acid, polycaprolactone, gelatin, zirconium-based hybrids, and others. The process of fabrication does not require clean room conditions and does not use hazard chemicals or high temperatures. The most beneficial property of 2PP is that it is capable of producing especially complex three-dimensional (3-D) structures, including devices with overhangs, without using any supportive structure. The flexibility in controlling geometries and feature sizes and the possibility to fabricate structures without the addition of new material layers makes this technique particularly appealing for fabrication of 3-D scaffolds for tissue engineering.
Keywords
- Hydrogels, Scaffolds, Two-photon polymerization
ASJC Scopus subject areas
- Engineering(all)
- Biomedical Engineering
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In: Biomedizinische Technik, Vol. 58, No. 5, 28.05.2013, p. 399-405.
Research output: Contribution to journal › Review article › Research › peer review
}
TY - JOUR
T1 - Laser microstructured biodegradable scaffolds
AU - Koroleva, Anastasia
AU - Kufelt, Olga
AU - Schlie-Wolter, Sabrina
AU - Hinze, Ulf
AU - Chichkov, Boris
PY - 2013/5/28
Y1 - 2013/5/28
N2 - The two-photon polymerization technique (2PP) uses non-linear absorption of femtosecond laser pulses to selectively polymerize photosensitive materials. 2PP has the ability to fabricate structures with a resolution from tens of micrometers down to hundreds of nanometers. Three-dimensional microstructuring by the 2PP technique provides many interesting possibilities for biomedical applications. This microstructuring technique is suitable with many biocompatible polymeric materials, such as polyethylene glycol, polylactic acid, polycaprolactone, gelatin, zirconium-based hybrids, and others. The process of fabrication does not require clean room conditions and does not use hazard chemicals or high temperatures. The most beneficial property of 2PP is that it is capable of producing especially complex three-dimensional (3-D) structures, including devices with overhangs, without using any supportive structure. The flexibility in controlling geometries and feature sizes and the possibility to fabricate structures without the addition of new material layers makes this technique particularly appealing for fabrication of 3-D scaffolds for tissue engineering.
AB - The two-photon polymerization technique (2PP) uses non-linear absorption of femtosecond laser pulses to selectively polymerize photosensitive materials. 2PP has the ability to fabricate structures with a resolution from tens of micrometers down to hundreds of nanometers. Three-dimensional microstructuring by the 2PP technique provides many interesting possibilities for biomedical applications. This microstructuring technique is suitable with many biocompatible polymeric materials, such as polyethylene glycol, polylactic acid, polycaprolactone, gelatin, zirconium-based hybrids, and others. The process of fabrication does not require clean room conditions and does not use hazard chemicals or high temperatures. The most beneficial property of 2PP is that it is capable of producing especially complex three-dimensional (3-D) structures, including devices with overhangs, without using any supportive structure. The flexibility in controlling geometries and feature sizes and the possibility to fabricate structures without the addition of new material layers makes this technique particularly appealing for fabrication of 3-D scaffolds for tissue engineering.
KW - Hydrogels
KW - Scaffolds
KW - Two-photon polymerization
UR - http://www.scopus.com/inward/record.url?scp=84897031870&partnerID=8YFLogxK
U2 - 10.1515/bmt-2013-0036
DO - 10.1515/bmt-2013-0036
M3 - Review article
C2 - 23729598
AN - SCOPUS:84897031870
VL - 58
SP - 399
EP - 405
JO - Biomedizinische Technik
JF - Biomedizinische Technik
SN - 0013-5585
IS - 5
ER -