Details
| Original language | English |
|---|---|
| Pages (from-to) | 91-97 |
| Number of pages | 7 |
| Journal | Current Pharmaceutical Biotechnology |
| Volume | 14 |
| Issue number | 1 |
| Publication status | Published - 2013 |
| Externally published | Yes |
Abstract
Computer assisted biofabrication of fully functional living tissue for regenerative medicine involves generation of complex three-dimensional constructs consisting of living cells and biomaterials. Laser BioPrinting (LaBP) based on laser-induced forward-transfer provides unique possibilities for the deposition of different living cells and biomaterials in a well-defined 3D structure. LaBP can be applied to generate scaffold-free 3D cell systems through a layer-by-layer technique by combining cell solutions with materials that are able to form stable gels. Also, it is used to precisely populate scaffolds with different cells and different cell densities. It was proven that printed cells are not affected by the laser printing procedure and that a differentiation of printed stem cells is not induced. Thus, LaBP is demonstrated as a promising tool for the ex vivo generation of tissue replacements.
Keywords
- Bioprinting, Cell printing, Laser induced forward transfer, Organ printing, Scaffold, Tissue engineering
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Biotechnology
- Pharmacology, Toxicology and Pharmaceutics(all)
- Pharmaceutical Science
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In: Current Pharmaceutical Biotechnology, Vol. 14, No. 1, 2013, p. 91-97.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Laser assisted cell printing
AU - Koch, L.
AU - Gruene, M.
AU - Unger, C.
AU - Chichkov, B.
PY - 2013
Y1 - 2013
N2 - Computer assisted biofabrication of fully functional living tissue for regenerative medicine involves generation of complex three-dimensional constructs consisting of living cells and biomaterials. Laser BioPrinting (LaBP) based on laser-induced forward-transfer provides unique possibilities for the deposition of different living cells and biomaterials in a well-defined 3D structure. LaBP can be applied to generate scaffold-free 3D cell systems through a layer-by-layer technique by combining cell solutions with materials that are able to form stable gels. Also, it is used to precisely populate scaffolds with different cells and different cell densities. It was proven that printed cells are not affected by the laser printing procedure and that a differentiation of printed stem cells is not induced. Thus, LaBP is demonstrated as a promising tool for the ex vivo generation of tissue replacements.
AB - Computer assisted biofabrication of fully functional living tissue for regenerative medicine involves generation of complex three-dimensional constructs consisting of living cells and biomaterials. Laser BioPrinting (LaBP) based on laser-induced forward-transfer provides unique possibilities for the deposition of different living cells and biomaterials in a well-defined 3D structure. LaBP can be applied to generate scaffold-free 3D cell systems through a layer-by-layer technique by combining cell solutions with materials that are able to form stable gels. Also, it is used to precisely populate scaffolds with different cells and different cell densities. It was proven that printed cells are not affected by the laser printing procedure and that a differentiation of printed stem cells is not induced. Thus, LaBP is demonstrated as a promising tool for the ex vivo generation of tissue replacements.
KW - Bioprinting
KW - Cell printing
KW - Laser induced forward transfer
KW - Organ printing
KW - Scaffold
KW - Tissue engineering
UR - http://www.scopus.com/inward/record.url?scp=84872554348&partnerID=8YFLogxK
U2 - 10.2174/138920113804805368
DO - 10.2174/138920113804805368
M3 - Article
C2 - 23570054
AN - SCOPUS:84872554348
VL - 14
SP - 91
EP - 97
JO - Current Pharmaceutical Biotechnology
JF - Current Pharmaceutical Biotechnology
SN - 1389-2010
IS - 1
ER -