IVP-VAE: Modeling EHR Time Series with Initial Value Problem Solvers

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  • Indian Institute of Technology Kharagpur (IITKGP)
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Original languageEnglish
Pages (from-to)16023-16031
Number of pages9
JournalProceedings of the AAAI Conference on Artificial Intelligence
Volume38
Issue number14
Publication statusPublished - 24 Mar 2024
Event38th AAAI Conference on Artificial Intelligence, AAAI 2024 - Vancouver, Canada
Duration: 20 Feb 202427 Feb 2024

Abstract

Continuous-time models such as Neural ODEs and Neural Flows have shown promising results in analyzing irregularly sampled time series frequently encountered in electronic health records. Based on these models, time series are typically processed with a hybrid of an initial value problem (IVP) solver and a recurrent neural network within the variational autoencoder architecture. Sequentially solving IVPs makes such models computationally less efficient. In this paper, we propose to model time series purely with continuous processes whose state evolution can be approximated directly by IVPs. This eliminates the need for recurrent computation and enables multiple states to evolve in parallel. We further fuse the encoder and decoder with one IVP solver utilizing its invertibility, which leads to fewer parameters and faster convergence. Experiments on three real-world datasets show that the proposed method can systematically outperform its predecessors, achieve state-of-the-art results, and have significant advantages in terms of data efficiency.

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Cite this

IVP-VAE: Modeling EHR Time Series with Initial Value Problem Solvers. / Xiao, Jingge; Basso, Leonie; Nejdl, Wolfgang et al.
In: Proceedings of the AAAI Conference on Artificial Intelligence, Vol. 38, No. 14, 24.03.2024, p. 16023-16031.

Research output: Contribution to journalConference articleResearchpeer review

Xiao, J, Basso, L, Nejdl, W, Ganguly, N & Sikdar, S 2024, 'IVP-VAE: Modeling EHR Time Series with Initial Value Problem Solvers', Proceedings of the AAAI Conference on Artificial Intelligence, vol. 38, no. 14, pp. 16023-16031. https://doi.org/10.48550/arXiv.2305.06741, https://doi.org/10.1609/aaai.v38i14.29534
Xiao, J., Basso, L., Nejdl, W., Ganguly, N., & Sikdar, S. (2024). IVP-VAE: Modeling EHR Time Series with Initial Value Problem Solvers. Proceedings of the AAAI Conference on Artificial Intelligence, 38(14), 16023-16031. https://doi.org/10.48550/arXiv.2305.06741, https://doi.org/10.1609/aaai.v38i14.29534
Xiao J, Basso L, Nejdl W, Ganguly N, Sikdar S. IVP-VAE: Modeling EHR Time Series with Initial Value Problem Solvers. Proceedings of the AAAI Conference on Artificial Intelligence. 2024 Mar 24;38(14):16023-16031. doi: 10.48550/arXiv.2305.06741, 10.1609/aaai.v38i14.29534
Xiao, Jingge ; Basso, Leonie ; Nejdl, Wolfgang et al. / IVP-VAE : Modeling EHR Time Series with Initial Value Problem Solvers. In: Proceedings of the AAAI Conference on Artificial Intelligence. 2024 ; Vol. 38, No. 14. pp. 16023-16031.
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title = "IVP-VAE: Modeling EHR Time Series with Initial Value Problem Solvers",
abstract = "Continuous-time models such as Neural ODEs and Neural Flows have shown promising results in analyzing irregularly sampled time series frequently encountered in electronic health records. Based on these models, time series are typically processed with a hybrid of an initial value problem (IVP) solver and a recurrent neural network within the variational autoencoder architecture. Sequentially solving IVPs makes such models computationally less efficient. In this paper, we propose to model time series purely with continuous processes whose state evolution can be approximated directly by IVPs. This eliminates the need for recurrent computation and enables multiple states to evolve in parallel. We further fuse the encoder and decoder with one IVP solver utilizing its invertibility, which leads to fewer parameters and faster convergence. Experiments on three real-world datasets show that the proposed method can systematically outperform its predecessors, achieve state-of-the-art results, and have significant advantages in terms of data efficiency.",
author = "Jingge Xiao and Leonie Basso and Wolfgang Nejdl and Niloy Ganguly and Sandipan Sikdar",
note = "Funding Information: This research was funded by the Federal Ministry of Education and Research (BMBF), Germany under the project LeibnizKILabor with grant No. 01DD20003; 38th AAAI Conference on Artificial Intelligence, AAAI 2024 ; Conference date: 20-02-2024 Through 27-02-2024",
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T2 - 38th AAAI Conference on Artificial Intelligence, AAAI 2024

AU - Xiao, Jingge

AU - Basso, Leonie

AU - Nejdl, Wolfgang

AU - Ganguly, Niloy

AU - Sikdar, Sandipan

N1 - Funding Information: This research was funded by the Federal Ministry of Education and Research (BMBF), Germany under the project LeibnizKILabor with grant No. 01DD20003

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AB - Continuous-time models such as Neural ODEs and Neural Flows have shown promising results in analyzing irregularly sampled time series frequently encountered in electronic health records. Based on these models, time series are typically processed with a hybrid of an initial value problem (IVP) solver and a recurrent neural network within the variational autoencoder architecture. Sequentially solving IVPs makes such models computationally less efficient. In this paper, we propose to model time series purely with continuous processes whose state evolution can be approximated directly by IVPs. This eliminates the need for recurrent computation and enables multiple states to evolve in parallel. We further fuse the encoder and decoder with one IVP solver utilizing its invertibility, which leads to fewer parameters and faster convergence. Experiments on three real-world datasets show that the proposed method can systematically outperform its predecessors, achieve state-of-the-art results, and have significant advantages in terms of data efficiency.

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