Details
| Original language | English |
|---|---|
| Pages (from-to) | 2560-2563 |
| Number of pages | 4 |
| Journal | Organic letters |
| Volume | 18 |
| Issue number | 11 |
| Early online date | 24 May 2016 |
| Publication status | Published - 3 Jun 2016 |
Abstract
The isolation, structure elucidation, and synthesis of antalid (1), a novel secondary metabolite from Polyangium sp., is described herein. The structure elucidation of 1 was performed with the aid of mass spectrometry, high field NMR experiments, and crystal structure analysis. The absolute configuration of antalid was confirmed through the Mosher ester method and ultimately by total synthesis. In addition, the biosynthetic origin of this hybrid PKS-NRPS natural product was unraveled by the in silico analysis of its biosynthetic gene cluster.
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Biochemistry
- Chemistry(all)
- Physical and Theoretical Chemistry
- Chemistry(all)
- Organic Chemistry
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In: Organic letters, Vol. 18, No. 11, 03.06.2016, p. 2560-2563.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Isolation, Structure Elucidation, Biosynthesis, and Synthesis of Antalid, a Secondary Metabolite from Polyangium species
AU - Tautz, Thomas
AU - Hoffmann, Judith
AU - Hoffmann, Thomas
AU - Steinmetz, Heinrich
AU - Washausen, Peter
AU - Kunze, Brigitte
AU - Huch, Volker
AU - Kitsche, Andreas
AU - Reichenbach, Hans
AU - Höfle, Gerhard
AU - Müller, Rolf
AU - Kalesse, Markus
PY - 2016/6/3
Y1 - 2016/6/3
N2 - The isolation, structure elucidation, and synthesis of antalid (1), a novel secondary metabolite from Polyangium sp., is described herein. The structure elucidation of 1 was performed with the aid of mass spectrometry, high field NMR experiments, and crystal structure analysis. The absolute configuration of antalid was confirmed through the Mosher ester method and ultimately by total synthesis. In addition, the biosynthetic origin of this hybrid PKS-NRPS natural product was unraveled by the in silico analysis of its biosynthetic gene cluster.
AB - The isolation, structure elucidation, and synthesis of antalid (1), a novel secondary metabolite from Polyangium sp., is described herein. The structure elucidation of 1 was performed with the aid of mass spectrometry, high field NMR experiments, and crystal structure analysis. The absolute configuration of antalid was confirmed through the Mosher ester method and ultimately by total synthesis. In addition, the biosynthetic origin of this hybrid PKS-NRPS natural product was unraveled by the in silico analysis of its biosynthetic gene cluster.
UR - http://www.scopus.com/inward/record.url?scp=84973454431&partnerID=8YFLogxK
U2 - 10.1021/acs.orglett.6b00810
DO - 10.1021/acs.orglett.6b00810
M3 - Article
AN - SCOPUS:84973454431
VL - 18
SP - 2560
EP - 2563
JO - Organic letters
JF - Organic letters
SN - 1523-7060
IS - 11
ER -